摘要
尽管急性白血病的治疗取得了很大进展,但复发和/或化疗难治性疾病的结果仍然较差。目前广泛的细胞毒性治疗与显着的发病率和新的治疗方法需要改善的结果有关。免疫治疗为基础的方法提供了一种替代的治疗急性白血病的作用机制。由于细胞表面抗原的表达,白血病特别是有针对性的治疗,如抗体为基础的治疗。基于潜在的非重叠毒性,与标准化疗的协同作用的可能性,并通过提供一种新的方法来克服化疗耐药性,抗体为基础的治疗已经显示出潜在的利益。标准的单克隆抗体修饰,包括药物共轭和联动T细胞,可进一步提高基于抗体的治疗的疗效。在标准方案上,确定理想结合抗体为基础的治疗的时机,可能会导致整体结果的改善。本文将概述抗体为基础的治疗用于治疗急性白血病的儿童和成人临床开发中,特别侧重于当前的战略和未来的发展。
关键词: 急性白血病,抗体治疗,研究,免疫调节药,一诺妥单抗,利妥昔单抗
Current Drug Targets
Title:Antibody Based Therapies in Acute Leukemia
Volume: 18 Issue: 3
Author(s): Nirali N. Shah.
Affiliation:
关键词: 急性白血病,抗体治疗,研究,免疫调节药,一诺妥单抗,利妥昔单抗
摘要: Despite great progress in the curative treatment of acute leukemia, outcomes for those with relapsed and/or chemotherapy-refractory disease remain poor. Current intensive cytotoxic therapies can be associated with significant morbidity and novel therapies are needed to improve outcomes. Immunotherapy based approaches provide an alternative mechanism of action in the treatment of acute leukemia. Due to cell surface antigen expression, leukemia in particular is amenable to targeted therapies, such as antibody-based therapy. Based on the potential for non-overlapping toxicity, the possibility of synergistic action with standard chemotherapy, and by providing a novel method to overcome chemotherapy resistance, antibody-based therapies have shown potential for benefit. Modifications to standard monoclonal antibodies, including drug conjugation and linkage to T-cells, may further enhance efficacy of antibody-based therapies. Identifying the ideal timing for incorporation of antibody-based therapies, within standard regimens, may lead to improvement in overall outcomes. This article will provide an overview of antibody-based therapies in clinical development for the treatment of acute leukemia in children and adults, with a particular focus on the current strategies and future developments.
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Nirali N. Shah. , Antibody Based Therapies in Acute Leukemia, Current Drug Targets 2017; 18 (3) . https://dx.doi.org/10.2174/1389450117666160905091459
DOI https://dx.doi.org/10.2174/1389450117666160905091459 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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