Abstract
Cystic fibrosis (CF) is a deadly genetic disease that affects the lungs and digestive system. A mutation in the CF transmembrane conductance regulator (CFTR) gene is the cause of the disease. How epigenetics contributes to CFTR expression is still poorly understood. Epigenetics is a mechanism that alters gene expression without changing the underlying DNA sequence. Epigenetic mechanisms include DNA methylation and histone modification. Both mechanisms have been implicated in CFTR gene regulation. Here we review epigenetic regulation of CFTR transcription while discussing potential epigenetic targeting strategies including DNA methyltransferase, histone deacetylase, and histone methyltransferase and demethylase inhibition. Because of the reversibility of epigenetics, targeting epigenetic mechanisms has been an attractive therapeutic approach. However, epigenetic targeting of CF disease is still at its infant stage.
Keywords: CFTR, cystic fibrosis, DNA methylation, epigenetics, histone acetylation, histone methylation.
Current Drug Targets
Title:Epigenetics in Cystic Fibrosis: Epigenetic Targeting of a Genetic Disease
Volume: 16 Issue: 9
Author(s): Nualpun Sirinupong and Zhe Yang
Affiliation:
Keywords: CFTR, cystic fibrosis, DNA methylation, epigenetics, histone acetylation, histone methylation.
Abstract: Cystic fibrosis (CF) is a deadly genetic disease that affects the lungs and digestive system. A mutation in the CF transmembrane conductance regulator (CFTR) gene is the cause of the disease. How epigenetics contributes to CFTR expression is still poorly understood. Epigenetics is a mechanism that alters gene expression without changing the underlying DNA sequence. Epigenetic mechanisms include DNA methylation and histone modification. Both mechanisms have been implicated in CFTR gene regulation. Here we review epigenetic regulation of CFTR transcription while discussing potential epigenetic targeting strategies including DNA methyltransferase, histone deacetylase, and histone methyltransferase and demethylase inhibition. Because of the reversibility of epigenetics, targeting epigenetic mechanisms has been an attractive therapeutic approach. However, epigenetic targeting of CF disease is still at its infant stage.
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Cite this article as:
Sirinupong Nualpun and Yang Zhe, Epigenetics in Cystic Fibrosis: Epigenetic Targeting of a Genetic Disease, Current Drug Targets 2015; 16 (9) . https://dx.doi.org/10.2174/1389450116666150416114514
DOI https://dx.doi.org/10.2174/1389450116666150416114514 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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