Abstract
The G-protein coupled receptor system is involved in a range of cell types and actions and as such has a universal potential in identifying cell functions.
The most widely explored system is that of the somatostatin receptors which has been exploited for both imaging and therapy. However, even with this fairly simple system, variation is seen in the behaviour of cells between patients and within different cell population within the patient.
Newer work will exploit different ligands in a wider range of both tumour types and non-oncological processes such as inflammation.
Keywords: Bombesin, Chemokines, G Protein Coupled Receptors, Inflammation, Imaging, Personalized medicine, Somatostatin Receptors, Targeted Therapy.
Current Pharmaceutical Design
Title:Radiolabeled Probes Targeting G-Protein-Coupled Receptors for Personalized Medicine
Volume: 20 Issue: 14
Author(s): John Buscombe
Affiliation:
Keywords: Bombesin, Chemokines, G Protein Coupled Receptors, Inflammation, Imaging, Personalized medicine, Somatostatin Receptors, Targeted Therapy.
Abstract: The G-protein coupled receptor system is involved in a range of cell types and actions and as such has a universal potential in identifying cell functions.
The most widely explored system is that of the somatostatin receptors which has been exploited for both imaging and therapy. However, even with this fairly simple system, variation is seen in the behaviour of cells between patients and within different cell population within the patient.
Newer work will exploit different ligands in a wider range of both tumour types and non-oncological processes such as inflammation.
Export Options
About this article
Cite this article as:
Buscombe John, Radiolabeled Probes Targeting G-Protein-Coupled Receptors for Personalized Medicine, Current Pharmaceutical Design 2014; 20 (14) . https://dx.doi.org/10.2174/13816128113196660660
DOI https://dx.doi.org/10.2174/13816128113196660660 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Using Nutrigenomics to Evaluate Apoptosis as a Preemptive Target in Cancer Prevention
Current Cancer Drug Targets Resveratrol and Lifespan in Model Organisms
Current Medicinal Chemistry Cytochrome P450-based Gene Therapy for Cancer Treatment: From Concept to the Clinic
Current Drug Metabolism Carbohydrates: Potential Sweet Tools Against Cancer
Current Medicinal Chemistry Aneurysm of the Communicating Vein Between the Left Renal Vein and Left Ascending Lumbar Vein Mimicking Retroperitoneal Lymphadenopathy: A Case Report
Current Medical Imaging Neuropeptide-Derived Antimicrobial Peptides from Invertebrates for Biomedical Applications
Current Medicinal Chemistry Mammalian Target of Rapamycin (mTOR) Inhibitors as Anti-Cancer Agents
Current Cancer Drug Targets Do We have a Satisfactory Cell Viability Assay? Review of the Currently Commercially-Available Assays
Current Drug Discovery Technologies Risk Assessment of the Use of Autonomous Parvovirus-Based Vectors
Current Gene Therapy Research Progress on the Mechanisms of Combined Bevacizumab and Radiotherapy
Recent Patents on Anti-Cancer Drug Discovery Biological and Clinical Significance of Polymorphisms in NAD(P)H: Quinone Oxidoreductase 1 (NQO1)
Current Pharmacogenomics Herpes Simplex Viruses in Antiviral Drug Discovery
Current Pharmaceutical Design Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin
Current Cancer Drug Targets Targeting Tumor Suppressor p53 for Cancer Therapy: Strategies, Challenges and Opportunities
Current Drug Targets DNA Methyltransferases Inhibitors from Natural Sources
Current Topics in Medicinal Chemistry Nanomedicine based on Nucleic Acids: Pharmacokinetic and Pharmacodynamic Perspectives
Current Pharmaceutical Biotechnology Semaphorins and their Receptors in Stem and Cancer Cells
Current Medicinal Chemistry Targeted Radionuclide Therapy - An Overview
Current Radiopharmaceuticals An overview of ABC and SLC Drug Transporter Gene Regulation
Current Drug Metabolism Applications of Lipid based Formulation Technologies in the Delivery of Biotechnology-based Therapeutics
Current Pharmaceutical Biotechnology