Abstract
The aim of the present investigation was to prepare coumarin matrix transdermal systems using the combinations of Eudragit RL-100/Eudragit RS-100. The formulations were evaluated for various physicochemical properties (thickness, weight variation, drug content uniformity, moisture content and water absorption uptake), in vitro release studies, in vitro skin permeation studies and skin irritation studies. In vitro skin permeation and skin irritation studies were carried out on rat skin and rabbit respectively. The drug–polymer interaction results revealed no interaction between the drug and the polymers. Drug content uniformity of the patches was found more than 98%. Variations in drug permeation profiles were observed among the formulations. From the results concluded that coumarin can be formulated into the transdermal matrix type patches to overcome the first pass effect, reduced frequency of administration of coumarin and sustain its release characteristics; the polymeric composition Eudragit RL and Eudragit RS (1:1) with 1mL of ethanol was found to be the best choice for the formulation of transdermal patches of coumarin among the formulation studied.
Keywords: Coumarin, Eudragit RL, Eudragit RS, Release studies, Transdermal patch
Current Drug Delivery
Title:Design and Evaluation of Matrix Diffusion Controlled Transdermal Patches of Coumarin
Volume: 10 Issue: 2
Author(s): S. Lakshmana Prabu, S. Thiyagarajan and T.N.K. Suriyaprakash
Affiliation:
Keywords: Coumarin, Eudragit RL, Eudragit RS, Release studies, Transdermal patch
Abstract: The aim of the present investigation was to prepare coumarin matrix transdermal systems using the combinations of Eudragit RL-100/Eudragit RS-100. The formulations were evaluated for various physicochemical properties (thickness, weight variation, drug content uniformity, moisture content and water absorption uptake), in vitro release studies, in vitro skin permeation studies and skin irritation studies. In vitro skin permeation and skin irritation studies were carried out on rat skin and rabbit respectively. The drug–polymer interaction results revealed no interaction between the drug and the polymers. Drug content uniformity of the patches was found more than 98%. Variations in drug permeation profiles were observed among the formulations. From the results concluded that coumarin can be formulated into the transdermal matrix type patches to overcome the first pass effect, reduced frequency of administration of coumarin and sustain its release characteristics; the polymeric composition Eudragit RL and Eudragit RS (1:1) with 1mL of ethanol was found to be the best choice for the formulation of transdermal patches of coumarin among the formulation studied.
Export Options
About this article
Cite this article as:
Lakshmana Prabu S., Thiyagarajan S. and Suriyaprakash T.N.K., Design and Evaluation of Matrix Diffusion Controlled Transdermal Patches of Coumarin, Current Drug Delivery 2013; 10 (2) . https://dx.doi.org/10.2174/1567201811310020003
DOI https://dx.doi.org/10.2174/1567201811310020003 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
Call for Papers in Thematic Issues
Advances of natural products, bio-actives and novel drug delivery system against emerging viral infections
Due to the increasing prevalence of viral infections and the ability of these human pathogens to develop resistance to current treatment strategies, there is a great need to find and develop new compounds to combat them. These molecules must have low toxicity, specific activity and high bioavailability. The most suitable ...read more
Electrospun Fibers as Drug Delivery Systems
In recent years, electrospun fibers have attracted considerable attention as potential platforms for drug delivery due to their distinctive properties and adaptability. These fibers feature a notable surface area-to-volume ratio and can be intentionally designed with high porosity, facilitating an increased capacity for drug loading and rendering them suitable for ...read more
Emerging Nanotherapeutics for Mitigation of Neurodegenerative Disorders
Conditions affecting the central nervous system (CNS) present a significant hurdle due to limited access of both treatments and diagnostic tools for the brain. The blood-brain barrier (BBB) acts as a barrier, restricting the passage of molecules from the bloodstream into the brain. The most formidable challenge facing scientists is ...read more
Nanotechnology Based Chemotherapy for the treatment of Head & Neck Cancer
The escalating recurrence rates observed in Head and Neck cancer, particularly within the chemo-therapeutically treated cohort (50-60%), can be attributed to the non-selective nature of current anticancer drug delivery modalities. In this context, nanotechnology-based drug delivery systems emerge as a promising avenue for achieving precise localization of therapeutic agents to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers