Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by selective neuronal loss, amyloid plaques and neurofibrillary tangles. Oxidative stress may play an important role in the pathogenesis of AD which is associated with the accumulation of β-amyloid (Aβ). Jatrorrhizine (JAT) is a novel tetrahydroisoquinoline alkaloid originally extracted from the Chinese herb coptidis rhizome. Our previous studies showed that JAT protected neuronallike cells against H2O2 -induced toxicity. In this study, we investigated the protective effects of JAT against Aβ25-35- induced cell death in rat cortical neurons. When the cortical neurons were exposed to 25μM Aβ25-35 for 24h, there was a significant reduction in cell viability and activities of SOD and GSH-Px. It also increased the production of malondialdehyde (MDA) and ROS but reduced MMP. Pretreatment of the cortical neurons with various concentrations of JAT (1-10μM) attenuated Aβ25-35-induced neurotoxicity markedly. JAT was also showed to suppress the activation of caspase-3 induced by Aβ25-35 and prevented the cytochrome c transporting into the cytosol. These results indicate that JAT demonstrates the neuroprotective effects against Aβ25-35-induced injury via its antioxidative potential, which may provide a therapeutical potential to AD.
Keywords: β-amyloid (25-35), JAT, Alzheimer’s disease, oxidative stress, apoptosis, antioxidative potential, malondialdehyde, neurofibrillary tangles, neurotoxicity, cortical neurons.
CNS & Neurological Disorders - Drug Targets
Title:The Protective Effects of Jatrorrhizine on β-Amyloid (25-35)-Induced Neurotoxicity in Rat Cortical Neurons
Volume: 11 Issue: 8
Author(s): Tao Luo, Wei Jiang, Yan Kong, Sheng Li, Feng He, Jie Xu and Hua-Qiao Wang
Affiliation:
Keywords: β-amyloid (25-35), JAT, Alzheimer’s disease, oxidative stress, apoptosis, antioxidative potential, malondialdehyde, neurofibrillary tangles, neurotoxicity, cortical neurons.
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by selective neuronal loss, amyloid plaques and neurofibrillary tangles. Oxidative stress may play an important role in the pathogenesis of AD which is associated with the accumulation of β-amyloid (Aβ). Jatrorrhizine (JAT) is a novel tetrahydroisoquinoline alkaloid originally extracted from the Chinese herb coptidis rhizome. Our previous studies showed that JAT protected neuronallike cells against H2O2 -induced toxicity. In this study, we investigated the protective effects of JAT against Aβ25-35- induced cell death in rat cortical neurons. When the cortical neurons were exposed to 25μM Aβ25-35 for 24h, there was a significant reduction in cell viability and activities of SOD and GSH-Px. It also increased the production of malondialdehyde (MDA) and ROS but reduced MMP. Pretreatment of the cortical neurons with various concentrations of JAT (1-10μM) attenuated Aβ25-35-induced neurotoxicity markedly. JAT was also showed to suppress the activation of caspase-3 induced by Aβ25-35 and prevented the cytochrome c transporting into the cytosol. These results indicate that JAT demonstrates the neuroprotective effects against Aβ25-35-induced injury via its antioxidative potential, which may provide a therapeutical potential to AD.
Export Options
About this article
Cite this article as:
Luo Tao, Jiang Wei, Kong Yan, Li Sheng, He Feng, Xu Jie and Wang Hua-Qiao, The Protective Effects of Jatrorrhizine on β-Amyloid (25-35)-Induced Neurotoxicity in Rat Cortical Neurons, CNS & Neurological Disorders - Drug Targets 2012; 11 (8) . https://dx.doi.org/10.2174/1871527311211080013
DOI https://dx.doi.org/10.2174/1871527311211080013 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nicotinamide Adenine Dinucleotide Based Therapeutics
Current Medicinal Chemistry Nanocarriers Conjugated with Cell Penetrating Peptides: New Trojan Horses by Modern Ulysses
Current Pharmaceutical Biotechnology Biological Markers of Alzheimers Disease and Mild Cognitive Impairment
Current Alzheimer Research Metal Ions and Metal Complexes in Alzheimer’s Disease
Current Pharmaceutical Design The Role of Mitochondria in Cancer Induction, Progression and Changes in Metabolism
Mini-Reviews in Medicinal Chemistry Hybrid Molecules Development: A Versatile Landscape for the Control of Antifungal Drug Resistance: A Review
Mini-Reviews in Medicinal Chemistry Molecular Pharmacology of the Glycine Receptor Chloride Channel
Current Pharmaceutical Design From Physiome to Pathome: A Systems Biology Model of Major Depressive Disorder and the Psycho-Immune-Neuroendocrine Network
Current Psychiatry Reviews The Role of Phosphorylation in Synucleinopathies: Focus on Parkinsons Disease
CNS & Neurological Disorders - Drug Targets Strategies of Engineering Nanoparticles for Treating Neurodegenerative Disorders
Current Drug Metabolism Are we Genomic Mosaics? Variations of the Genome of Somatic Cells can Contribute to Diversify our Phenotypes
Current Genomics Organelle Stress Sensors and Cell Death Mechanisms in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Mitochondrial Targeting for Development of Novel Drug Strategies in Brain Injury
Central Nervous System Agents in Medicinal Chemistry Recent Advances in Nanoneurology for Drug Delivery to the Brain
Current Nanoscience Neurobiology of Depression and Novel Antidepressant Drug Targets
Current Pharmaceutical Design 6-hydroxydopamine Lesion of the Mesolimbic Dopamine System Alters Morphine-Induced Conditioned Reinforcement
Current Psychopharmacology Potential Use of Nanomedicine for Drug Delivery Across the Blood-Brain Barrier in Healthy and Diseased Brain
CNS & Neurological Disorders - Drug Targets GPE and GPE Analogues as Promising Neuroprotective Agents
Mini-Reviews in Medicinal Chemistry Traumatic Brain Injury: Preclinical Imaging Diagnostic(s) and Therapeutic Approaches
Current Pharmaceutical Design Population-based Study of Risk Polymorphisms Associated with Vascular Disorders and Dementia
Current Genomics