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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Cells with Minimal Expression of the JAK/STAT Pathway Related Proteins STAT5a and the Prolactin Receptor: Evidence of an Alternate Prolactin Receptor Isoform in Breast Disease

Author(s): G. L. Bratthauer, M. D. Stamatakos and T. N. Vinh

Volume 17, Issue 1, 2010

Page: [104 - 108] Pages: 5

DOI: 10.2174/092986610789909467

Price: $65


Usually, wherever breast STAT5a is present, PRLR is reduced; without STAT5a PRLR becomes abundant. Five breast lesions essentially lacking both were tested immunohistochemically for PRLR isoforms. The intermediate isoform was essentially only detected in these lesions. In some breast lesions PRLR isoforms may be involved in JAK/STAT pathway disturbances.

Keywords: Breast, STAT5a, PRLR, Immunohistochemistry, Intermediate Isoform

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