Cells with Minimal Expression of the JAK/STAT Pathway Related Proteins STAT5a and the Prolactin Receptor: Evidence of an Alternate Prolactin Receptor Isoform in Breast Disease

Title: Cells with Minimal Expression of the JAK/STAT Pathway Related Proteins STAT5a and the Prolactin Receptor: Evidence of an Alternate Prolactin Receptor Isoform in Breast Disease

Volume: 17 Issue: 1

Author(s): G. L. Bratthauer, M. D. Stamatakos and T. N. Vinh

Affiliation:

Keywords: Breast, STAT5a, PRLR, Immunohistochemistry, Intermediate Isoform

Abstract: Usually, wherever breast STAT5a is present, PRLR is reduced; without STAT5a PRLR becomes abundant. Five breast lesions essentially lacking both were tested immunohistochemically for PRLR isoforms. The intermediate isoform was essentially only detected in these lesions. In some breast lesions PRLR isoforms may be involved in JAK/STAT pathway disturbances.

Cite this article as:

Bratthauer L. G., Stamatakos D. M. and Vinh N. T., Cells with Minimal Expression of the JAK/STAT Pathway Related Proteins STAT5a and the Prolactin Receptor: Evidence of an Alternate Prolactin Receptor Isoform in Breast Disease, Protein & Peptide Letters 2010; 17(1) . https://dx.doi.org/10.2174/092986610789909467