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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ

Author(s): Jason Lauer, Debarshi Banerjee, Denton Shanks, Huaien Dai, Yu-Xi Gong, Om Prakash and Dolores Takemoto

Volume 17, Issue 1, 2010

Page: [1 - 10] Pages: 10

DOI: 10.2174/092986610789909485

Price: $65

Abstract

The region (101-112) of C1B domain in PKCγ plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.

Keywords: Protein kinase C gamma, C1B domain, NMR, Structure function relationship, Serine 109

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