Abstract
The region (101-112) of C1B domain in PKCγ plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.
Keywords: Protein kinase C gamma, C1B domain, NMR, Structure function relationship, Serine 109
Protein & Peptide Letters
Title: NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ
Volume: 17 Issue: 1
Author(s): Jason Lauer, Debarshi Banerjee, Denton Shanks, Huaien Dai, Yu-Xi Gong, Om Prakash and Dolores Takemoto
Affiliation:
Keywords: Protein kinase C gamma, C1B domain, NMR, Structure function relationship, Serine 109
Abstract: The region (101-112) of C1B domain in PKCγ plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.
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Cite this article as:
Lauer Jason, Banerjee Debarshi, Shanks Denton, Dai Huaien, Gong Yu-Xi, Prakash Om and Takemoto Dolores, NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ, Protein & Peptide Letters 2010; 17 (1) . https://dx.doi.org/10.2174/092986610789909485
DOI https://dx.doi.org/10.2174/092986610789909485 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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