Inhibitory Effects of β-Cyclodextrin and Trehalose on Nanofibril and AGE Formation During Glycation of Human Serum Albumin

Title: Inhibitory Effects of β-Cyclodextrin and Trehalose on Nanofibril and AGE Formation During Glycation of Human Serum Albumin

Volume: 16 Issue: 6

Author(s): Esmaeel Sharifi, Naghmeh Sattarahmady, Mehran Habibi-Rezaei, Mohammad Farhadi, Nader Sheibani, Faizan Ahmad and Ali Akbar Moosavi-Movahedi

Affiliation:

Keywords: Diabetes, trehalose, β-cyclodextrin, glycation, HSA, glucose

Abstract: The effects of β-cyclodextrin (β-CyD) and trehalose on glycation of human serum albumin (HSA) were studied. These additives reduced AGEs and nanofibril formation of HSA under in vitro glycation conditions and improved its helical structure. These were accomplished through direct interactions of them with HSA and alterations in solute-protein interactions.

Cite this article as:

Sharifi Esmaeel, Sattarahmady Naghmeh, Habibi-Rezaei Mehran, Farhadi Mohammad, Sheibani Nader, Ahmad Faizan and Moosavi-Movahedi Akbar Ali, Inhibitory Effects of β-Cyclodextrin and Trehalose on Nanofibril and AGE Formation During Glycation of Human Serum Albumin, Protein & Peptide Letters 2009; 16(6) . https://dx.doi.org/10.2174/092986609788490212