Abstract
C-terminal fragment of the Botulinum neurotoxin A comprises two sub-domains including HC-N and HC-C. Here, the conformational change of HC-N was studied by spectroscopic techniques. The results indicated that the partially unfolded state forms during unfolding of HC-N. This finding may shed light on poorly – known features of the protein.
Keywords: H, -N, botulinum neurotoxin A, circular dichroism, fluorescence spectroscopy, molten globule like state
Protein & Peptide Letters
Title: Identification of a Molten Globule Like State in H -N Fragment of Botulinum Neurotoxin A: Shedding Light on the Poorly-Known Features of a Conserved Sub-Domain
Volume: 16 Issue: 6
Author(s): Leila Hasani, Bijan Ranjbar, Mahmood Tavallaie and Majid Sadeghizadeh
Affiliation:
Keywords: H, -N, botulinum neurotoxin A, circular dichroism, fluorescence spectroscopy, molten globule like state
Abstract: C-terminal fragment of the Botulinum neurotoxin A comprises two sub-domains including HC-N and HC-C. Here, the conformational change of HC-N was studied by spectroscopic techniques. The results indicated that the partially unfolded state forms during unfolding of HC-N. This finding may shed light on poorly – known features of the protein.
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Cite this article as:
Hasani Leila, Ranjbar Bijan, Tavallaie Mahmood and Sadeghizadeh Majid, Identification of a Molten Globule Like State in H -N Fragment of Botulinum Neurotoxin A: Shedding Light on the Poorly-Known Features of a Conserved Sub-Domain, Protein & Peptide Letters 2009; 16 (6) . https://dx.doi.org/10.2174/092986609788490131
DOI https://dx.doi.org/10.2174/092986609788490131 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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