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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Identification of a Molten Globule Like State in H -N Fragment of Botulinum Neurotoxin A: Shedding Light on the Poorly-Known Features of a Conserved Sub-Domain

Author(s): Leila Hasani, Bijan Ranjbar, Mahmood Tavallaie and Majid Sadeghizadeh

Volume 16, Issue 6, 2009

Page: [660 - 663] Pages: 4

DOI: 10.2174/092986609788490131

Price: $65

Abstract

C-terminal fragment of the Botulinum neurotoxin A comprises two sub-domains including HC-N and HC-C. Here, the conformational change of HC-N was studied by spectroscopic techniques. The results indicated that the partially unfolded state forms during unfolding of HC-N. This finding may shed light on poorly – known features of the protein.

Keywords: H, -N, botulinum neurotoxin A, circular dichroism, fluorescence spectroscopy, molten globule like state


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