Recent Progress in the Application of Exosome Analysis in Ovarian Cancer Management

Title:Recent Progress in the Application of Exosome Analysis in Ovarian Cancer Management

Volume: 24

Author(s): Vahideh Keyvani, Zari Naderi Ghale-noie, Samaneh Mollazadeh, Reihaneh Alsadat Mahmoudian, Elnaz Ghorbani, Hamid Naderi, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A Ferns, Amir Avan*Kazem Anvari

Affiliation:

• Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
• College of Medicine, University of Warith Al-Anbiyaa, Karbala, Iraq
• Faculty of Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane 4059, Australia

Keywords: Ovarian cancer, exosomes, bioactive molecules, biomarkers, delivery vehicles.

Abstract: Exosomes are very small (nano-sized) vesicles participating in tumor development by involvement in intercellular communication mediated by transferring biocomponents. Exosomes appear to play vital roles in various cancer development, such as ovarian cancer, a common malignancy in women. Several hallmarks of ovarian cancer are reported to be affected by the exosome-- mediated cellular cross-talk, including modulating peritoneal dissemination and chemoresistance. Since the expression of some biomolecules, such as miRNAs and mRNA, is changed in ovarian cancer, these exo-biomolecules can be applied as prognostic, diagnostic, and therapeutic biomarkers. Also, the selective loading of specific chemotherapeutic agents into exosomes highlights these biocarries as potential delivery devices. Exosomes could be artificially provided and engineered to better target the site of interest in ovarian cancer. In the present review, we summarize the notable achievement of exosome application in ovarian cancer management to gain applicable transitional insight against this cancer.

Cite this article as:

Keyvani Vahideh, Naderi Ghale-noie Zari, Mollazadeh Samaneh, Alsadat Mahmoudian Reihaneh, Ghorbani Elnaz, Naderi Hamid, Khazaei Majid, Hassanian Seyed Mahdi, A Ferns Gordon, Avan Amir*, Anvari Kazem, Recent Progress in the Application of Exosome Analysis in Ovarian Cancer Management, Current Cancer Drug Targets 2024; 24 () . https://dx.doi.org/10.2174/0115680096281906231213055422