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Current Radiopharmaceuticals

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ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

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Mini-Review Article

Current State of 44Ti/44Sc Radionuclide Generator Systems and Separation Chemistry

Author(s): Christine E. Schmidt, Leah Gajecki, Melissa A. Deri and Vanessa A. Sanders*

Volume 16, Issue 2, 2023

Published on: 13 December, 2022

Page: [95 - 106] Pages: 12

DOI: 10.2174/1874471016666221111154424

Price: $65

Abstract

In recent years, there has been an increased interest in 44Ti/44Sc generators as an onsite source of 44Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of 44Sc make it a viable candidate for positron emission tomography (PET) imaging. This review discusses current 44Ti/44Sc generator designs, focusing on their chemistry, drawbacks, post-elution processing, and relevant preclinical studies of the 44Sc for potential PET radiopharmaceuticals.

Keywords: Scandium, titanium, generators, PET, radioisotope production, diagnostics, radiolabeling.

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