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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Clinical Trial

NAPA-紫杉醇联合吉西他滨治疗转移性胰腺癌的临床疗效和安全性：NAPA研究

卷 20, 期 11, 2020

页: [887 - 895] 页: 9

弟呕挨: 10.2174/1568009620999200918122426

价格: $65

摘要

背景：III期MPACT试验证明了吉西他滨（Gem）联合Nab-紫杉醇（Nab-P）相对于单独使用吉西他滨在先前未经治疗的转移性胰腺导管腺癌（PDAC）患者中的优势。这项研究的目的是评估Gem / Nab-P在常规临床实践中的作用。 方法：从2015年1月至2018年12月，接受吉西他滨和Nab-紫杉醇联合一线治疗的转移性PDAC患者纳入多中心回顾性观察研究。对功效，预后和预测指标进行了探索性分析。 结果：该队列包括115名患者（中位年龄65 [50-84]岁），表现良好（ECOG PS 0-1）。中位总体生存期（OS）为11个月（95％CI; 9-13），中位无进展生存期（PFS）为6个月（95％CI 5-7）。分别有44例和30例患者实现了部分缓解和疾病稳定，总体疾病控制率（DCR）为64.3％。中性粒细胞减少症的3-4级血液学毒性频率为22.61％，贫血为5.22％，血小板减少症为3.48％。 2.61％的患者记录为3级虚弱。没有4级非血液学事件的报道。 51.3％的患者必须减少剂量。 结论：我们的结果证实了吉西他滨和纳布紫杉醇一线方案在实际人群中转移性PDAC中的有效性和安全性。

关键词: 转移性胰腺腺癌，联合化疗，纳布紫杉醇，吉西他滨，预后因素，癌症。

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