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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Case Report

Autoimmune Polyendocrine Syndrome Complicated by Pulmonary Hypertension

Author(s): Olga E. Disoteo, Benedetta Zampetti, Andrea Garascia, Roberto Attanasio* and Renato Cozzi

Volume 21, Issue 3, 2021

Published on: 31 July, 2020

Page: [561 - 565] Pages: 5

DOI: 10.2174/1871530320666200801033106

Price: $65

Abstract

A 24-years old female was admitted for acute renal failure, melanoderma, hyponatremia, and hyperkalemia. The clinical suspicion of Addison’s disease was confirmed by laboratory test and the appropriate replacement therapy with corticosteroids and fludrocortisone was started. In the meantime primary hypothyroidism and diabetes mellitus type 1 were disclosed and treated, thus fulfilling a diagnosis of autoimmune polyendocrine syndrome type 2. Eighteen months later she was admitted for right-sided heart failure. The work-up allowed to diagnose pulmonary arterial hypertension. Here, we report the clinical course and discuss the putative link between these two rare diseases.

Keywords: Autoimmune polyendocrine syndrome, pulmonary arterial hypertension, hypothyroidism, hypoadrenalism, diabetes mellitus.

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