Abstract
In the HIV infection, the short time-scale between the HIV-induced cardiovascular events and the onset of antiretroviral therapy elicits a thrombophilic co-factor that worsens the induced atherosclerosis. We compared the factor VIII plasma activity, previously implicated in arterial and venous thrombosis, with a surrogate marker of atherosclerosis, the carotid intima-media thickness, and with the usual atherosclerosis risk factors in 154 HIV infected outpatients. The FVIII plasma activity is significantly associated with the carotid intima-media thickness and, strongly, with blood glucose and triglycerides levels. A raised FVIII plasma activity is an important feature of the metabolic syndrome and a putative co-factor of HAART induced cardiovascular events. Thus the prevention of the HAARTinduced cardio-vascular events should probably not be exclusively focused on atherosclerosis but likewise on the thrombus formation process.
Keywords: highly active antiretroviral therapy, FVIII plasma levels, Protease Inhibitors, cardiovascular events, CD4 count
Current HIV Research
Title: Correlations Between Carotid IMT, Factor VIII Activity Level and Metabolic Disturbances: A Cardio-Vascular Risk Factor in the HIV Positive Persons
Volume: 5 Issue: 3
Author(s): Luc de Saint Martin, Elisabeth Pasquier, Olivier Vandhuick, Bertrand Arnaud, Sophie Vallet, Jerome Duchemin, Veronique Bellein and Luc Bressollette
Affiliation:
Keywords: highly active antiretroviral therapy, FVIII plasma levels, Protease Inhibitors, cardiovascular events, CD4 count
Abstract: In the HIV infection, the short time-scale between the HIV-induced cardiovascular events and the onset of antiretroviral therapy elicits a thrombophilic co-factor that worsens the induced atherosclerosis. We compared the factor VIII plasma activity, previously implicated in arterial and venous thrombosis, with a surrogate marker of atherosclerosis, the carotid intima-media thickness, and with the usual atherosclerosis risk factors in 154 HIV infected outpatients. The FVIII plasma activity is significantly associated with the carotid intima-media thickness and, strongly, with blood glucose and triglycerides levels. A raised FVIII plasma activity is an important feature of the metabolic syndrome and a putative co-factor of HAART induced cardiovascular events. Thus the prevention of the HAARTinduced cardio-vascular events should probably not be exclusively focused on atherosclerosis but likewise on the thrombus formation process.
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de Saint Martin Luc, Pasquier Elisabeth, Vandhuick Olivier, Arnaud Bertrand, Vallet Sophie, Duchemin Jerome, Bellein Veronique and Bressollette Luc, Correlations Between Carotid IMT, Factor VIII Activity Level and Metabolic Disturbances: A Cardio-Vascular Risk Factor in the HIV Positive Persons, Current HIV Research 2007; 5 (3) . https://dx.doi.org/10.2174/157016207780636498
DOI https://dx.doi.org/10.2174/157016207780636498 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
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