Proteinase K-Resistant Aggregates of Recombinant Prion Protein PrP-(23-98) Are Toxic to Cultured Cells

Author(s): Noriyuki Shiraishi, Yoko Inai, Yoshito Ihara

Journal Name: Protein & Peptide Letters

Volume 16 , Issue 1 , 2009


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Abstract:

Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur.

Keywords: Prion protein, PrP-(23-98), aggregates, cytotoxicity, apoptosis, PrP-deficient cell line

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2009
Page: [91 - 96]
Pages: 6
DOI: 10.2174/092986609787049475

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