Structure and Function of the Important Internalins of Listeria monocytogenes

Title:Structure and Function of the Important Internalins of Listeria monocytogenes

Volume: 22 Issue: 8

Author(s): Shabir A. Mir*

Affiliation:

• Department of Medical Laboratory Sciences, College of Applied Medical Science, Majmaah University, Al Majmaah- 11952,Saudi Arabia

Keywords: Listeriosis, pathogenesis, virulence, virulence factors, internalins, Listeria monocytogenes.

Abstract: Listeria monocytogenes, a facultative intracellular gram-positive pathogen, is the causative agent of the disease listeriosis. The virulence of this intracellular bacterium is dependent on the coordinated activity of various bacterial factors, which are in turn tightly controlled by a specific set of regulators. The various virulence factors employed by L. monocytogenes for its infection cycle are well reported in literature. Although the internalins of L. monocytogenes have been studied in detail, their structural details are currently scattered and fragmented. Therefore, in the current review, we provide a brief account of the existing knowledge on structural details of the key internalins of L. monocytogenes and also highlight the recent advances in their functional aspects.

Cite this article as:

Mir A. Shabir *, Structure and Function of the Important Internalins of Listeria monocytogenes, Current Protein & Peptide Science 2021; 22 (8) . https://dx.doi.org/10.2174/1389203722666210902163300