Objective: This study investigated the relationship between neural activities and retinal structures
associated with working memory (WM) in older adults with mild cognitive impairment (MCI).
Methods: Eleven older adults with MCI and 29 healthy controls (60 to 73 years old) were tested. All
participants underwent an event-related potential (ERP) recording while performing the two-back
memory task. The Optical coherence tomography angiography (OCT-A) was administered to examine
the perfusion and vessel density in the retina.
Results: Results showed that WM performance in the MCI group was negatively associated with ERP
latencies in central parietal regions (CP6 and CP8) (ps< 0.05). The left nasal vessel and perfusion densities
were negatively correlated with the latencies in these two central parietal regions and positively
related to WM performance only in the MCI group (ps< 0.05).
Conclusion: The findings on WM, central parietal brain activity, and left nasal vessel and perfusion
densities in the retina help us gain a better understanding of the neural and retinal underpinnings of WM
in relation to MCI.