Obesity is the major disorder characterized by excessive fat in the body. Various factors responsible for the obesity are dietary, lifestyle, genetic and environmental factors. Last two decades witnessed an enormous increase of obesity and its co-morbidities in people worldwide, thus making it the fifth major cause of human death. As per recent report of WHO, 38 million children (age < 5 years) were overweight or obese in 2019, and according to Organization for Economic Cooperation and Development (OECD) report almost 1 in 4 people are obese. For the treatment of obesity various synthetic drugs are available but on the other side these are associated with severe adverse effects. To overcome this problem and in the view of current situation, researchers emphasise more on the development of natural products for the management of obesity. Primary and secondary metabolites like polyphenols, alkaloids, saponins and flavonoids derived from various plants worldwide are used to develop formulation for the management of obesity. The phytoconstituents exert their action by suppressing proliferation of adipocytes, inducing apoptosis of adipocytes, inhibiting lipogenesis, activating lipases, stimulating fatty acid β-oxidation, diminishing inflammatory responses or by conquering oxidative stress. This review also highlights the importance of nanoencapsulation technique which enhances the efficacy of phytoconstituents by improving solubility, stability, and bioavailability to fight against obesity and comorbidity.