Role, Significance and Association of microRNA-10a/b in Physiology of Cancer

(E-pub Ahead of Print)

Author(s): Khaled M. Elgeshy*, Abdel Hady A. Abdel Wahab

Journal Name: MicroRNA


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Abstract:

MicroRNAs “miRNAs” are small non-coding RNAs that regulate translation of mRNA and protein mainly on post-transcriptional level. And as global expression profiling of miRNAs has demonstrated a wide spectrum of aberration that are correlated with several diseases, miRNA-10a/b were of the first miRNAs to be examined to be involved in abnormal activities upon dysregulation, including many types of cancers and progressive diseases. It is expected for the same miRNAs to behave in an inconsistent fashion within different types of cancers, or even in the same type upon different contexts or phases. This review is an attempt to provide a set of information about our updated understanding of miRNA-10a/b and their clinical significance, molecular targets, current research gaps and possibly future applications of such potent regulators, and help to uncover the logic behind such behavior and possible approaches to exploit such unique entities.

Keywords: microRNA , Cancer, biomarker, EMT, therapy, metastasis, risk factor

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2211536609666201026155519
Price: $95

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