Osteoarthritis(OA) is a common degenerative orthopedic disease with multiple pathologic
changes in joints affecting large populations worldwide. No treatment can reverse the progress of
OA. Since exosomes were first reported in 1983, researches have been conducted to explore the
mechanisms and therapeutic potential of exosomes in treating OA. Exosomes derived from Mesenchymal
stem cells have attracted increasing attention in tackling the disease. This article summarizes
the current advances and challenges in exosomes for OA, which may providea reference for further
Keywords: MSC exosomes, exosomes, osteoarthritis, micro-RNA, cytokines, microenvironment.
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