Selective Estrogen Receptor Modulators (SERMs): Mechanistic Insights Against Microbial Infections

Author(s): Aakriti Garg, Balraj Singh, Ruchika Sharma, Arti Singh, Anoop Kumar*

Journal Name: Current Molecular Medicine

Volume 20 , Issue 2 , 2020

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Background: Infections are one of the leading causes of death worldwide and currently available treatments remain unsatisfactory due to rise in the cases of antimicrobial resistance. Thus, there is a need for the development of new drugs with different mechanisms of action. However, the development of new antimicrobials agents is a long and expensive process. Hence, most of the pharmaceutical companies are looking forward to repurposing the already available drugs against microbial infections.

Methodology: The data related to SERMs and microbial infection has been extracted from Pub Med (from January 1997 to December 2018). A total of 101 studies have been published from 1997 -2018 regarding SERMs and microbial infections.

Results: On the basis of inclusion and exclusion criteria, 25 studies have been included for the analysis of level of evidence regarding antimicrobial effects of SERMs. Emerging reports have indicated the antimicrobial property of selective estrogen receptor modulators (SERMs) against normal and resistant strains under in vitro and in vivo conditions against wide variety of microorganisms through different mechanisms of action.

Conclusion: In conclusion, SERMs could be developed as a broad spectrum antimicrobial agent alone or in combination with existing antimicrobial agents.

Keywords: SERMs, drug repurposing, drug resistance, antimicrobial activity, microbial infections, estrogen.

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Year: 2020
Page: [102 - 115]
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DOI: 10.2174/1566524019666191014112133
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