MicroRNAs are short non-coding RNAs involved in critical biological processes. In the
past decade, the deregulation of miRNAs has been well-documented in a wide range of human diseases,
Overexpression and downregulation of miRNAs affect cellular pathways that contribute to carcinogenesis
and tumor progression. This evidence makes miRNAs a suitable candidate for therapeutic applications
and leads to developing strategies to manipulate their expression.
Consistently, in vitro and in vivo studies show that Let-7, miR-10b, miR-21, miR-34, miR-155 and
miR-221 are promising targets to develop miRNAs-based therapy for human malignancies.
The purpose of this review is to discuss the different approaches that can be used to restore or reduce
miRNAs expression in human cancer and the therapeutic implications.