Alterations of the X Chromosome in Lymphocytes of Alzheimer’s Disease Patients

Author(s): Biljana Spremo-Potparevic, Vladan Bajic, George Perry, Lada Zivkovic

Journal Name: Current Alzheimer Research

Volume 12 , Issue 10 , 2015

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Chromosomal alterations as a sign of genetic instability are a feature of Alzheimer’s disease (AD). Assessment of the genetic instability of non-neuronal cells of AD patients may provide a method to diagnose or monitor prognosis of the disease. Considering the importance of X chromosome alterations in the possible etiology of AD females, we used fluorescent in situ hybridization (FISH) for the centromere region of the X chromosome to determine aneuploidy, for a possible correlation with premature centromere division (PCD, X) in lymphocytes of AD females and age-matched controls. In AD patients, our results showed a marked and significant increase in the frequency of the X chromosome aneuploidy comparing with age matched controls (p<0.001). Also, a significant difference was detected in the PCD, X frequency between AD females when compared with age matched controls (p<0.001). In addition, a strong (R2=0.97, n=20) and significant (p<0.001) correlation was found between the frequency of aneuploidy and PCD, X in the AD group. Our results support the view that AD is a generalized systematic disease where PCD is to be considered as a stable sign of disease leading to aneuploidy.

Keywords: Alzheimer’s disease, aneuploidy, FISH, peripheral blood lymphocytes, PCD, X chromosome.

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Article Details

Year: 2015
Published on: 27 October, 2015
Page: [990 - 996]
Pages: 7
DOI: 10.2174/1567205012666151027124154
Price: $65

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