Title:Proline-Rich Peptides: Multifunctional Bioactive Molecules as New Potential Therapeutic Drugs
VOLUME: 16 ISSUE: 2
Author(s):Alberto Vitali
Affiliation:Istituto di Chimica del Riconoscimento Molecolare, CNR, c/o Istituto di biochimica e Biochimica Clinica, L.go F. Vito, 1 ,00168, Rome, Italy.
Keywords:Antimicrobial, drugs, polyproline-II helix, proline rich motifs, proline-rich peptides, protein-protein interactions.
Abstract:Proline-rich peptides (PRPs) include a large and heterogeneous group of small-medium sized peptides
characterized by the presence of proline residues often constituting peculiar sequences. This feature confers
them a typical structure that determines the various biological functions endowed by these molecules. In
particular the left-handed-polyproline-II helix is essential for the expression of the antimicrobial, immunomodulatory,
antioxidant properties and to finely modulate protein-protein interactions, thus playing crucial
roles in many cell signal transduction pathways. These peptides are widely diffuse in the animal kingdom and in humans,
where they are present in many tissues and biological fluids. This review highlights the most relevant biological properties
of these peptides, focusing on the potential therapeutic role that the PRPs may play as a promising source of new peptidebased
novel drugs.
