Title:An Overview on Pharmacokinetics, Disposition, and Safety of Nanoparticles in Ocular Applications
VOLUME: 14 ISSUE: 8
Author(s):Xingyi Li, Lingli Li, Zhaoliang Zhang and Hao Chen
Affiliation:School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical College, 270 Xueyuan Road China.
Keywords:Disposition, drug delivery, nanoparticles, ocular application pharmacokinetics.
Abstract:In the past three decades, the application of nanotechnology in ophthalmology has gained considerable progress for the treatment
of ocular diseases including anterior and posterior diseases. Results strongly suggest that delivery of ocular medicines, especially
those based on macromolecular agents such as proteins, peptides, and nucleotides, are greatly enhanced by the use of nanotechnology.
Generally, ophthalmic drugs are delivered to ocular tissues by precorneal instillation and intravitreal injections. An ideal ocular drug delivery
system should have certain desirable properties, such as excellent corneal and conjunctival penetration, prolonged residence time,
sustained release, and easy administration. It should also be nonirritating and noncytotoxic. This review places in perspective the importance
of nanoparticles in the pharmacokinetics and disposition of ocularly administered drugs. Furthermore, the safety and compatibility
of nanoparticles for ocular administration are specifically discussed.
