MicroRNA Functions and Potential Clinical Utility in Glioblastoma

Author(s): Sean E. Lawler

Journal Name: Current Signal Transduction Therapy

Volume 8 , Issue 1 , 2013

Become EABM
Become Reviewer


A flurry of recent research has established that microRNAs have fundamental roles in the biology of the aggressive brain tumor, glioblastoma multiforme. MicroRNAs function in multiple hallmark biological characteristics of glioblastoma, including cell proliferation, invasion, glioma stem cell behavior, and angiogenesis as well as sensitivity to conventional therapies. Many of these microRNAs intersect with key pathways in glioblastoma, indicating their importance in the disease. MicroRNAs also have prognostic potential, may be useful biomarkers and can be used to define subclasses of glioblastoma. MicroRNAs have also shown therapeutic activity in preclinical cancer models.

Keywords: MicroRNA, glioblastoma, therapeutic, biomarker, subclassification, biological regulatory networks, non-coding RNAs

promotion: free to download

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Published on: 14 February, 2013
Page: [36 - 44]
Pages: 9
DOI: 10.2174/1574362411308010006

Article Metrics

PDF: 15