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Combinatorial Chemistry & High Throughput Screening
ISSN (Print): 1386-2073
ISSN (Online): 1875-5402
VOLUME: 10
ISSUE: 10
DOI: 10.2174/138620707783220356      Price:  $58









Microwave-Assisted Synthesis of Bioactive Quinazolines and Quinazolinones

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Author(s): Thierry Besson and Elizabeth Chosson
Pages 903-917 (15)
Abstract:
This paper aims to review recent developments in the synthesis of quinazolines and quinazolinone derivatives under conditions that include the application of microwave heating in the ring forming step. Recently, two reviews on the synthesis and chemistry of natural and synthetic quinazolines and quinazolinones have been published. This review highlights significant examples where microwave heating has been either synthetically enabling or has provided a key advantage over conventional thermal methods. Wherever possible, this review will focus on chemistry carried out using monomode systems and well-designed type of instrumentation. The review is grouped according to the main heterocycle types in order of increasing complexity; commencing with quinazolines and their derivatives. The microwave-assisted synthesis of quinazolines and quinazolinones will be classified and based on the substitution patterns of the ring system. Syntheses of heterocyclic systems of particular biological or commercial interest are emphasized.
Keywords:
Heterocycles, quinazolines, quinazolin-4-ones, natural products, bioactive compounds, microwave irradiation, graphite, solvent-free chemistry
Affiliation:
Universite de Rouen, INSA de Rouen, CNRS UMR 6014, C.O.B.R.A.- I.R.C.O.F., UFR Medecine-Pharmacie, 22 Boulevard Gambetta, F-76183 Rouen Cedex 1, France.