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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Applications of the Combination of Microwave and Parallel Synthesis in Medicinal Chemistry

Author(s): Jesus Alcazar, Gaston Diels and Bruno Schoentjes

Volume 10, Issue 10, 2007

Page: [918 - 932] Pages: 15

DOI: 10.2174/138620707783220383

Price: $65


The blending of microwave heating and parallel chemistry is a logical consequence of the significant rate enhancement and higher product yield afforded by microwave technology and the increase in productivity afforded by combinatorial chemistry. For this reason, this combination has become increasingly popular in the organic chemistry community. The current review highlights the application of this approach as a way to increase the rate of analogue synthesis in medicinal chemistry.

Keywords: opioid receptor agonists, Piperazine Derivatives, Tropanylidene Derivatives, HIV-1 protease, malaria parasites, Obesity

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