Abstract
Breast cancer is one of the most common malignancies affecting women; thus, much effort has been put into understanding the genetics of predisposition to breast cancer as well as identifying factors involved in tumor progression and cancer prognosis. Conventional genetics was used to map and clone the two breast / ovarian cancer predisposition genes, BRCA1 and BRCA2. However, the vast majority of breast cancer cases are of a sporadic nature, likely due to a combination of environmental and genetic factors. Other genes have been identified via the analysis of protein interactions, screens based on inverse genomics, yeast two-hybrid assays, far Westerns, GST-pull downs and chromatography / mass spectrometry have been used to identify a number of proteins that interact with BRCA1 or BRCA2. Biological characteristics such as expression levels, protein stability and phosphorylation as well as the biological roles of the BRCA proteins in DNA repair and transcription have also led to the identification of o ther proteins involved in breast cancer. Recent advances in microarray analysis have allowed the identification of further genetic factors by comparing the transcription profiles of cell lines with varying levels of BRCA1 expression or drug resistance and tumors from patientswith or without BRCA1 / 2 mutations or with different pathobiological types of tumors or prognoses. Additionally, microarray analysis at the DNA level allows for the identification of genes that have been amplified or deleted during cancer progression, and tumor tissue arrays can be used to analyze hundreds of samples simultaneously for the expression of previously identified genetic factors.
Current Genomics
Title: Recent Advances in the Identification of Genetic and Biochemical Components of Breast Cancer Predisposition
Volume: 3 Issue: 5
Author(s): M. K. Sauer
Affiliation:
Abstract: Breast cancer is one of the most common malignancies affecting women; thus, much effort has been put into understanding the genetics of predisposition to breast cancer as well as identifying factors involved in tumor progression and cancer prognosis. Conventional genetics was used to map and clone the two breast / ovarian cancer predisposition genes, BRCA1 and BRCA2. However, the vast majority of breast cancer cases are of a sporadic nature, likely due to a combination of environmental and genetic factors. Other genes have been identified via the analysis of protein interactions, screens based on inverse genomics, yeast two-hybrid assays, far Westerns, GST-pull downs and chromatography / mass spectrometry have been used to identify a number of proteins that interact with BRCA1 or BRCA2. Biological characteristics such as expression levels, protein stability and phosphorylation as well as the biological roles of the BRCA proteins in DNA repair and transcription have also led to the identification of o ther proteins involved in breast cancer. Recent advances in microarray analysis have allowed the identification of further genetic factors by comparing the transcription profiles of cell lines with varying levels of BRCA1 expression or drug resistance and tumors from patientswith or without BRCA1 / 2 mutations or with different pathobiological types of tumors or prognoses. Additionally, microarray analysis at the DNA level allows for the identification of genes that have been amplified or deleted during cancer progression, and tumor tissue arrays can be used to analyze hundreds of samples simultaneously for the expression of previously identified genetic factors.
Export Options
About this article
Cite this article as:
Sauer K. M., Recent Advances in the Identification of Genetic and Biochemical Components of Breast Cancer Predisposition, Current Genomics 2002; 3 (5) . https://dx.doi.org/10.2174/1389202023350264
DOI https://dx.doi.org/10.2174/1389202023350264 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
NF-κB Blockers Gifted by Mother Nature: Prospectives in Cancer Cell Chemosensitization
Current Pharmaceutical Design Antiviral Drugs in the Prophylaxis of HBV Infection
Current Medicinal Chemistry Polyethyleneimine-Based Nanocarriers for Gene Delivery
Current Pharmaceutical Design Vitamin D and Cancer Mortality: Systematic Review of Prospective Epidemiological Studies
Anti-Cancer Agents in Medicinal Chemistry Reduced Nicotinamide Adenine Dinucleotide (NADH) Fluorescence for the Detection of Cell Death
Anti-Cancer Agents in Medicinal Chemistry IgG4 Related Syndrome: Another Multiorgan Disease in the Interest Field of Internal Medicine
Current Pharmaceutical Design Sorafenib (BAY 43-9006): Review of Clinical Development
Current Clinical Pharmacology Monitoring and Surveillance of Obesity in the United States
Current Nutrition & Food Science L-Thyroxine Acts as a Hormone as well as a Prohormone at the Cell Membrane
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Therapeutic Drugs in Bone Loss-Associated Disorders: Clinical Outcomes and Challenges
Current Drug Targets Aromatase Inhibitors Evolution as Potential Class of Drugs in the Treatment of Postmenopausal Breast Cancer Women
Mini-Reviews in Medicinal Chemistry Synthetic Aziridines in Medicinal Chemistry: A Mini-Review
Mini-Reviews in Medicinal Chemistry Hybrid PET/MRI for In Vivo Imaging of Cancer: Current Clinical Experiences and Recent Advances
Current Medical Imaging The Role of the ATP-Binding Cassette Transporter P-Glycoprotein in the Transport of β-Amyloid Across the Blood-Brain Barrier
Current Pharmaceutical Design Recombinant Human Serum Albumin Fusion Proteins and Novel Applications in Drug Delivery and Therapy
Current Pharmaceutical Design Mucosal T Cell Proliferation and Apoptosis in Inflammatory Bowel Disease
Current Drug Targets Polymeric Nanoparticles of Aromatase Inhibitors: A Comprehensive Review
Current Pharmaceutical Design STAT Inhibition in the Treatment of Cancer: Transcription Factors as Targets for Molecular Therapy
Current Cancer Therapy Reviews Long-circulating Targeted Nanoparticles for Cancer Therapy
Current Nanoscience Synthesis, Antioxidant, Anticancer and Antiviral Activities of Novel Quinoxaline Hydrazone Derivatives and their Acyclic C-Nucleosides
Medicinal Chemistry