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Review Article

刺激反应型纳米载体在乳腺癌治疗中的应用

卷 27, 期 15, 2020

页: [2494 - 2513] 页: 20

弟呕挨: 10.2174/0929867325666181009120610

价格: $65

摘要

Stimuli-responsive drug-delivery nanocarriers (DDNs)作为乳腺癌治疗的一种替代药物，在文献中得到了越来越多的报道。刺激响应型ddn的材料可以对内在/化学刺激(pH、氧化还原和酶)和外在/物理刺激(超声、近红外光(NIR)、磁场和电流)做出剧烈的反应。此外,他们可以使用不同的开发策略,如与信号分子功能化,导致几个优点,如改善药物脂溶的药物的性质,与肿瘤组织选择性降低系统性毒性作用,控制释放不同的刺激,这些都是提高基础治疗乳腺癌治疗的有效性。因此，本文综述了对刺激有反应的DDNs在乳腺癌治疗中的应用。我们将讨论分为内在刺激和外在刺激，并分别详细说明了它们的定义和应用。最后，我们的目标是在乳腺癌模型的体内评估这些刺激反应型DDNs在体外控制药物释放的能力和对乳腺癌治疗的影响。

关键词: 刺激反应药物纳米载体，内在/化学刺激，外在/物理刺激，乳腺癌治疗，近红外光(NIR)，脂溶性药物。

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