摘要
背景:子宫内膜异位症是一种炎症性妇科疾病,伴有慢性炎症。白细胞介素(IL)-1是主要由单核细胞和巨噬细胞产生的最重要的免疫和促炎因子之一。研究表明来自IL-1家族的细胞因子在子宫内膜相关性疾病中的作用,特别是在子宫内膜异位症中。 方法:基于PubMed和Medline数据库的电子文献检索,获取IL-1细胞因子家族细胞因子对子宫内膜异位症发病机制和发展的影响,包括1950年1月至2017年7月期间的相关资料,在已发表的研究中。 结果:IL-1家族细胞因子网络的损害可能导致子宫内膜异位症患者腹腔内免疫系统激活的改变。异常的异位子宫内膜细胞粘附,植入和增殖的特性可能是控制IL-1的抑制能力降低的结果。子宫内膜异位症患者腹腔液和血清中IL-1α,pro-IL-1β,成熟IL-1β和sIL-1R2与sIL-1RAcP之间的失衡可能与将急性炎症转化为慢性炎症的能力相关。尽管腹膜巨噬细胞在受影响的妇女的腹膜腔内分泌更多的抗炎IL-1Rα和更少的促炎性IL-1,但炎症仍然发展。 结论:这一观察结果清楚地表明IL-1活性在腹膜腔水平的具体调节机制中显着不足。子宫内膜异位症中所有研究的细胞因子之间的不平衡可能会使腹膜炎症升高,并因此导致子宫内膜异位症。
关键词: 子宫内膜异位症,炎症,白细胞介素-1,白细胞介素-1受体,腹膜液,血清。
Current Medicinal Chemistry
Title:The Delicate Balance between the Good and the Bad IL-1 Proinflammatory Effects in Endometriosis
Volume: 25 Issue: 18
关键词: 子宫内膜异位症,炎症,白细胞介素-1,白细胞介素-1受体,腹膜液,血清。
摘要: Background: Endometriosis is an inflammatory gynaecological disease with an associated chronic inflammation. Interleukin(IL)-1 is one of the most important immune and proinflammatory factors, produced mainly by monocytes and macrophages. Studies indicate the role of the cytokine from IL-1 family in endometrium-related disorders, particularly in endometriosis.
Methods: The information about the impact of cytokine from IL-1 cytokine family on the pathogenesis and development of endometriosis was obtained with an electronic literature search based on the PubMed and Medline databases, spanning the period of January 1950 to July 2017 and includes associated references in the published studies.
Results: The impairment of the IL-1 family cytokine-network may lead to changes in the activation of immune system in the peritoneal cavity of women with endometriosis. The aberrant ectopic endometrial cell properties of adhesion, implantation and proliferation may be the result of a reduced suppressive capacity controlling the IL-1. The imbalance between IL-1α, pro-IL-1β, mature IL-1β and sIL-1R2 and sIL-1RAcP in the peritoneal fluid and serum of women with endometriosis may be linked to the ability of transforming an acute inflammation into a chronic one. Despite the fact that peritoneal macrophages secrete more antiinflammatory IL-1Ra and less proinflammatory IL-1 in the peritoneal cavity in affected women, the inflammation still develops.
Conclusions: This observation clearly suggested a significant inadequacy in the specific regulatory mechanisms of IL-1 activity at the peritoneal cavity level. The imbalance between all studied cytokines in endometriosis may escalate peritoneal inflammation and, in consequence, develop endometriosis.
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Cite this article as:
The Delicate Balance between the Good and the Bad IL-1 Proinflammatory Effects in Endometriosis, Current Medicinal Chemistry 2018; 25 (18) . https://dx.doi.org/10.2174/0929867325666180111093547
DOI https://dx.doi.org/10.2174/0929867325666180111093547 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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