摘要
癌症是一种广泛的疾病,其特点是死亡率高。为了提高生存率或促进有效的治疗,需要在早期准确可靠的诊断。正因为如此,人们不断推动发展敏感的方法,这些方法可以用于癌症的诊断。目前的诊断依赖于癌症生物标志物的定量,这些分子在体液或组织中是可测量的,并表明生理过程中有随后的病理表现。这一贡献回顾了电化学免疫传感器领域的最新进展,该领域可用于检测在广泛的浓度范围内发生的癌症生物标志物,其中包括极低水平的肿瘤标志物,这在疾病的早期阶段是典型的。综述了几种用于生物标志物分析的抗体标签,并与电化学检测相结合。多生物标志物分析的潜力,其无可争议的临床影响,对准确的诊断,也是突出的。
关键词: 癌症,诊断,生物标志物,电化学检测,免疫传感器,多重检测。
Current Medicinal Chemistry
Title:Immunosensors in Early Cancer Diagnostics: From Individual to Multiple Biomarker Assays
Volume: 25 Issue: 33
关键词: 癌症,诊断,生物标志物,电化学检测,免疫传感器,多重检测。
摘要: Cancer is a widespread disease characterized by high mortality. To improve the survival rate or facilitate effective therapy, accurate and reliable diagnosis at an early stage is needed. For this reason, there is a continuous push to develop sensitive methods which can be used in cancer diagnosis. Current diagnosis relies on the quantification of cancer biomarkers defined as molecules that are measurable in body fluids or tissues and indicate a change in physiological processes with subsequent pathological manifestations. This contribution reviews recent developments in the area of electrochemical immunosensors applicable for the detection of cancer biomarkers that occur in a wide concentration range including extremely low levels, which are typical for the early stage of the disease. A summary of various antibody labels used for biomarker analysis and combined with electrochemical detection is presented. The potential of multiple biomarker analysis, with its indisputable clinical impact for accurate diagnosis, is also highlighted.
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Cite this article as:
Immunosensors in Early Cancer Diagnostics: From Individual to Multiple Biomarker Assays, Current Medicinal Chemistry 2018; 25 (33) . https://dx.doi.org/10.2174/0929867324666171121101245
DOI https://dx.doi.org/10.2174/0929867324666171121101245 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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