摘要
背景:由于其优异的物理化学性质,金纳米粒子(AuNPs)最近被引入作为有前景的纳米粒子。叶酸是细胞增殖的必需维生素。因此,AuNP与叶酸的表面官能化可能为开发提高基于新纳米技术的癌症诊断和治疗效率的策略提供了巨大的潜力。在这项研究中,我们回顾了最近在各种叶酸结合金纳米粒子(FAuNPs)的设计和生物医学应用方面取得的进展。 方法:我们在书目数据库中进行了结构化搜索,并提供了相关论文的综合列表。 (1)制备F-AuNPs的方法,(2)F-AuNPs在计算机断层扫描(CT)中的应用,以及(3)F-AuNPs在靶向癌症治疗中的用途。 结果:选择96篇论文作为评论。因此,我们解释了制造各种类型F-AuNPs的非共价键和共价键方法。描述了F-AuNP在使用CT扫描模式的癌症诊断中的特定应用。另外,深入阐述了F-AuNPs在靶向放射治疗,化疗和热疗中的应用。在热疗部分,我们对基于F-AuNP的激光,射频和基于超声波的热疗方法提出了一些额外的解释。 结论:本综述确定了F-AuNPs在当前正在全球范围内进行的癌症研究中的重要作用。这次审查的结果证实,F-AuNP是一种新的治疗药物,具有同时进行癌症治疗和诊断的巨大潜力。
关键词: 纳米技术,癌症,叶酸,金纳米粒子,胸片,CT扫描。
Current Medicinal Chemistry
Title:A Nanotechnology-based Strategy to Increase the Efficiency of Cancer Diagnosis and Therapy: Folate-conjugated Gold Nanoparticles
Volume: 24 Issue: 39
关键词: 纳米技术,癌症,叶酸,金纳米粒子,胸片,CT扫描。
摘要: Background: Gold nanoparticles (AuNPs), owing to their elegant physicochemical properties, have recently been introduced as promising theranostic nanoparticles. Folic acid is a necessary vitamin for cell proliferation. Accordingly, the surface functionalization of AuNP with folic acid may offer a great potential for the development of a strategy to increase the efficiency of cancer diagnosis and therapy based on the new nanotechnology. In this study, we have reviewed the recent progress made in the design and the biomedical application of various folate-conjugated gold nanoparticles (FAuNPs).
Methods: We performed a structured search in bibliographic databases and made a comprehensive list of relevant papers. The main subjects considered in this review included (1) methods for the preparation of F-AuNPs, (2) applications of F-AuNPs in computed tomography (CT), and (3) the use of F-AuNPs in targeted cancer therapy.
Results: As many as 96 papers were selected for the review. Accordingly, we explained the noncovalent and the covalent methods of fabricating the various types of F-AuNPs. Particular applications of F-AuNP in cancer diagnosis using the CT scan modality were described. In addition, the applications of F-AuNPs in targeted radiation therapy, chemotherapy, and hyperthermia were elucidated in depth. In the hyperthermia section, we presented certain extra explanations on F-AuNP-based laser, radiofrequency, and ultrasoundbased hyperthermia methods.
Conclusion: This review identifies the important roles of F-AuNPs in current cancer studies that are being undertaken worldwide. The findings of this review confirm that F-AuNP is a new theranostic agent, which has a great potential for simultaneous cancer therapy and diagnosis.
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A Nanotechnology-based Strategy to Increase the Efficiency of Cancer Diagnosis and Therapy: Folate-conjugated Gold Nanoparticles, Current Medicinal Chemistry 2017; 24 (39) . https://dx.doi.org/10.2174/0929867324666170810154917
DOI https://dx.doi.org/10.2174/0929867324666170810154917 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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