摘要
背景:乳腺癌占近三分之一的癌症,是女性中最常见的癌症。乳腺癌的死亡率估计为14%。因此,精确诊断早期意识和任何阶段的有效治疗都是乳腺癌生存的关键。乳房X光检查是最常见的检测乳腺癌的技术。然而,钼靶辐射剂量对患者有害。幸运的是,磁共振成像(Mri)可以在没有任何辐射剂量的情况下诊断乳腺癌,而增强的磁共振成像(Mri)可以使乳腺癌更早、诊断。因此,作为对比材料,超顺磁性氧化铁基纳米探针(SPION)已经引起了广泛的关注。 目的:综述近年来SPIONS作为多功能热敏剂的研究进展。 方法:除了SPION的合成和表面修饰外,还讨论了被动和主动靶向成像。此外,本文还进一步描述了一系列潜在的乳腺癌治疗方法。CH为光动力疗法、光热疗法、化疗和磁热疗。 结论:SPIONs的制备和表面修饰对乳腺癌的影像学诊断和进一步的潜在治疗具有重要意义。
关键词: 超顺磁性氧化铁纳米探针,热敏剂,磁共振成像,光动力疗法,药物输送,乳腺癌。
Current Medicinal Chemistry
Title:Recent Advances in Superparamagnetic Iron Oxide Based Nanoprobes as Multifunctional Theranostic Agents for Breast Cancer Imaging and Therapy
Volume: 25 Issue: 25
关键词: 超顺磁性氧化铁纳米探针,热敏剂,磁共振成像,光动力疗法,药物输送,乳腺癌。
摘要: Background: Breast cancer accounts for nearly one in three cancers, and it is the most common cancer diagnosed among women. The death rate of breast cancer is estimated to be 14%. Hence, accurate diagnosis in early stage and effective treatment in any stage are critical for the survival of breast cancer. Mammogram has been the most common technique administered to detect breast cancer. However, the radiation dose from mammogram is harmful to patients. Fortunately, magnetic resonance imaging (MRI) can diagnose breast cancer without any radiation dose, and enhanced MRI can make earlier and differential diagnosis. Therefore, as contrast materials, superparamagnetic iron oxide based nanoprobes (SPIONs) have generated a great deal of attention.
Objective: This review covers recent advances in SPIONs as multifunctional theranostic agents.
Methods: Besides synthesis and surface modification of SPIONs, passive and active targeted imaging is also discussed. Moreover, a serial of potential therapy for breast cancer is further described, such as photodynamic therapy, photothermal therapy, chemotherapy and magnetic hyperthermia therapy.
Conclusion: Preparation and surface modification of SPIONs is critical for imaging diagnosis of breast cancer and further potential treatment.
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Cite this article as:
Recent Advances in Superparamagnetic Iron Oxide Based Nanoprobes as Multifunctional Theranostic Agents for Breast Cancer Imaging and Therapy, Current Medicinal Chemistry 2018; 25 (25) . https://dx.doi.org/10.2174/0929867324666170705144642
DOI https://dx.doi.org/10.2174/0929867324666170705144642 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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