摘要
背景:像印度的令人印象深刻的生物学特性一样,其化学方面也提高了科学家对该领域的兴趣。对药物化学的详细了解是必要的,以充分利用它的药物。 方法:使用基于文献的文献检索工具,如Pubmed和Scifinder,进行基因检测和化学修饰。相关文献涵盖到2016年。提供了生物活性聚氨酯衍生物的结构。 结果:从Embelia ribes浆果提取或通过全合成获得的纯棉被应用于许多生物测定。半合成和全合成方法导致新的高亲和力来源于关键蛋白质靶标的抑制剂和具有改善的药理学性质(例如,具有更好的水溶性或作为药物载体体系的应用)的新型丝氨酸衍生物。 结论:本综述概述了优质(半)合成丝氨酸衍生物(包括其生物活性)领域的丰富化学成分和最新发展。
关键词: 天竺葵,天然产物,苯醌,抗氧化剂,药物设计,(半))合成丝氨酸衍生物
Current Medicinal Chemistry
Title:Chemical and Biological Aspects of the Natural 1,4-Benzoquinone Embelin and its (semi-)Synthetic Derivatives
Volume: 24 Issue: 18
关键词: 天竺葵,天然产物,苯醌,抗氧化剂,药物设计,(半))合成丝氨酸衍生物
摘要: Background: Like the impressive biological properties of embelin, its chemical aspects have raised the interest of scientists in the field as well. A detailed understanding of the chemistry of embelin is necessary to fully exploit it medicinally.
Methods: Search for embelin isolation and its chemical modifications was carried out using web-based literature searching tools such as Pubmed and Scifinder. Pertinent literature is covered up to 2016. Structures of bioactive embelin derivatives are provided. Results: Pure embelin, obtained from Embelia ribes berries extraction or by total synthesis, was applied for a number of biological assays. Semi-synthetic and total synthetic approaches led to new high affinity embelin-derived inhibitors of crucial protein targets and to new embelin derivatives with improved pharmacological properties (e.g., with better water-solubility or as applications for drug carrier systems). Conclusion: This review provides a summary of the rich chemistry of embelin and the latest developments in the field of optimized (semi-)synthetic embelin derivatives including their biological activities.Export Options
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Cite this article as:
Chemical and Biological Aspects of the Natural 1,4-Benzoquinone Embelin and its (semi-)Synthetic Derivatives, Current Medicinal Chemistry 2017; 24 (18) . https://dx.doi.org/10.2174/0929867324666170116125731
DOI https://dx.doi.org/10.2174/0929867324666170116125731 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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