摘要
胃癌是世界范围内癌症相关死亡的主要原因之一。胃癌患者通常是无症状的,并在晚期才能得到诊断,寻求新的预后和新诊断生物标志物的识别是十分必要的。最近,microRNA成为分子调节剂,对不同恶性肿瘤的发病和进展中起着关键作用,其中包括胃癌。越来越多研究表明一些已知循环的miRNAs如let-7a,miR-21,miR-16、miR-93,miR - 103,mir-192a,以及组织特异性miRNAs,如miR-18a,miR-10b,mir-544,miR-195,miR-378,miR-34a的异常激活受胃癌影响。此外,越来越多的研究表明miRNA和耐药机制有关,这表明其调制可作为克服化疗耐药的潜在方法。基于这些事实,本文总结了最近对能对患者进行早期诊断,预后及治疗的生物标志物的循环和组织特异性miRNA进行研究的临床前和临床研究。
关键词: 胃癌, miRNA,循环生物标志物,组织特异性标志物。
Current Medicinal Chemistry
Title:Circulating microRNAs as Potential Diagnostic Biomarkers and Therapeutic Targets in Gastric Cancer: Current Status and Future Perspectives
Volume: 23 Issue: 36
Author(s): Hamed Mirzaei, Sara Khataminfar, Saeid Mohammadparast, Soudabeh Shahid Sales, Mina Maftouh, Mohsen Mohammadi and Miganoosh Simonian, Seyed Mohammd Reza Parizadeh, Seyed Mahdi Hassanian, Amir Avan
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关键词: 胃癌, miRNA,循环生物标志物,组织特异性标志物。
摘要: Gastric cancer is among the leading causes of cancer related death worldwide. Patients with gastric cancer are typically asymptomatic, and diagnosed at late stages, supporting the need for the identification of novel prognostic and diagnostic biomarkers. Recently, microRNAs have emerged as molecular regulators that can play key roles in pathogenesis and progression of different malignancies, including gastric cancer. There is a growing body of evidence showing the aberrant activation of some known circulating miRNAs, e.g. let-7a, miR-21, miR-16, miR-93, miR- 103, miR-192a s well as tissue specific-miRNAs, e.g. miR-18a, miR-10b, miR-544, miR-195, miR-378, miR-34a, miR-145 in patients affected by gastric cancer, which involved with modulation of gastric-cancer-associated genes. In addition, there are mounting evidences on the value of miRNAs which are detected to be associated with drug-resistance mechanisms; suggesting their modulation as a potential approach to overcome chemo-resistance. Attuned with these facts, in this review we highlight several recent preclinical and clinical studies performed on circulating and tissue-specific miRNAs as promising biomarkers for detection of patients at early stages, prediction of prognosis, and monitoring of the patients in response to therapy.
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Hamed Mirzaei, Sara Khataminfar, Saeid Mohammadparast, Soudabeh Shahid Sales, Mina Maftouh, Mohsen Mohammadi and Miganoosh Simonian, Seyed Mohammd Reza Parizadeh, Seyed Mahdi Hassanian, Amir Avan , Circulating microRNAs as Potential Diagnostic Biomarkers and Therapeutic Targets in Gastric Cancer: Current Status and Future Perspectives, Current Medicinal Chemistry 2016; 23 (36) . https://dx.doi.org/10.2174/0929867323666160818093854
DOI https://dx.doi.org/10.2174/0929867323666160818093854 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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