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Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Human Umbilical Cord Blood Cells and Diabetes Mellitus: Recent Advances

Author(s): Alluru S. Reddi, Neil Kothari, Kishore Kuppasani and Norman Ende

Volume 10 , Issue 3 , 2015

Page: [266 - 270] Pages: 5

DOI: 10.2174/1574888X10666141212122421

Price: $65

Abstract

Stem cell therapy for patients with diabetes is an area of great interest to both scientists and clinicians. Human umbilical cord blood cells (HUCBCs) are being increasingly used as a source of stem cells for cell-based therapy for diabetes because these cells can differentiate into pancreatic islet β-cells. Administration of HUCBCs has been shown to lower blood glucose levels in diabetic animal models. The use of autologous HUCBC transfusion in type 1 diabetic children has not shown any benefit. However, “Stem Cell Educator” therapy has shown promise in long term lowering of blood glucose levels in both type 1 and type 2 diabetic patients. In this review, we will briefly discuss recent advances in HUCBC therapy in the treatment of diabetes and some of its complications.

Keywords: β-cells, clinical trials, diabetes mellitus, differentiation, human umbilical cord blood, stem cells, stem cell educator therapy.


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