Abstract
A technical improvement enabling efficient and reproducible stem cell cultures is one of the most important aspects in stem cell research and cell-based therapy. For this purpose, researchers have used various cytokine cocktails and gene transfection techniques to proliferate stem cells. However, stem cell fate can reportedly be determined by physical stimuli such as gravity, electrical fields, and magnetic fields. In this regard, we have developed a novel technique utilizing a clinostat, a device capable of generating a controlled microgravity environment for robust maintenance of stem cell state. Here, we review our recent progress in expansion and differentiation of stem cells grown under simulated microgravity environment and their utility for transplantation in animal models of cartilage deficiency and neurotrauma.
Keywords: Simulated microgravity, stem cell, cell differentiation, cell-based therapy.
Current Biotechnology
Title:Simulated Microgravity Based Stem Cell Cultures Enhance Their Utility for Cell-Based Therapy
Volume: 2 Issue: 3
Author(s): Yumi Kawahara and Louis Yuge
Affiliation:
Keywords: Simulated microgravity, stem cell, cell differentiation, cell-based therapy.
Abstract: A technical improvement enabling efficient and reproducible stem cell cultures is one of the most important aspects in stem cell research and cell-based therapy. For this purpose, researchers have used various cytokine cocktails and gene transfection techniques to proliferate stem cells. However, stem cell fate can reportedly be determined by physical stimuli such as gravity, electrical fields, and magnetic fields. In this regard, we have developed a novel technique utilizing a clinostat, a device capable of generating a controlled microgravity environment for robust maintenance of stem cell state. Here, we review our recent progress in expansion and differentiation of stem cells grown under simulated microgravity environment and their utility for transplantation in animal models of cartilage deficiency and neurotrauma.
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Cite this article as:
Kawahara Yumi and Yuge Louis, Simulated Microgravity Based Stem Cell Cultures Enhance Their Utility for Cell-Based Therapy, Current Biotechnology 2013; 2 (3) . https://dx.doi.org/10.2174/22115501113029990020
DOI https://dx.doi.org/10.2174/22115501113029990020 |
Print ISSN 2211-5501 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-551X |
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