Abstract
Dual-modality contrast agents, such as radiolabeled nanoparticles, are promising candidates for a number of diagnostic applications, since they combine the advantages of two different imaging modalities, namely SPECT or PET imaging with MR imaging. The benefit of such a combination is to more accurately interpret disease and abnormalities in vivo, by exploiting the advantages of each imaging technique, i.e. high sensitivity for SPECT/PET, high resolution anatomical information for MRI. In this review article, we provide an overview of recent findings in the synthesis, evaluation and application of radiolabeled iron oxide nanoparticles as dual-modality SPECT/MRI and PET/MRI imaging probes.
Keywords: Magnetic nanoparticles, iron oxide, radiolabeling, dual modality imaging, SPECT/MRI, PET/MRI
Current Topics in Medicinal Chemistry
Title:Radiolabeled Iron Oxide Nanoparticles As Dual-Modality SPECT/MRI and PET/MRI Agents
Volume: 12 Issue: 23
Author(s): Penelope Bouziotis, Dimitrios Psimadas, Theodoros Tsotakos, Dimosthenis Stamopoulos and Charalampos Tsoukalas
Affiliation:
Keywords: Magnetic nanoparticles, iron oxide, radiolabeling, dual modality imaging, SPECT/MRI, PET/MRI
Abstract: Dual-modality contrast agents, such as radiolabeled nanoparticles, are promising candidates for a number of diagnostic applications, since they combine the advantages of two different imaging modalities, namely SPECT or PET imaging with MR imaging. The benefit of such a combination is to more accurately interpret disease and abnormalities in vivo, by exploiting the advantages of each imaging technique, i.e. high sensitivity for SPECT/PET, high resolution anatomical information for MRI. In this review article, we provide an overview of recent findings in the synthesis, evaluation and application of radiolabeled iron oxide nanoparticles as dual-modality SPECT/MRI and PET/MRI imaging probes.
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Cite this article as:
Bouziotis Penelope, Psimadas Dimitrios, Tsotakos Theodoros, Stamopoulos Dimosthenis and Tsoukalas Charalampos, Radiolabeled Iron Oxide Nanoparticles As Dual-Modality SPECT/MRI and PET/MRI Agents, Current Topics in Medicinal Chemistry 2012; 12 (23) . https://dx.doi.org/10.2174/1568026611212230007
DOI https://dx.doi.org/10.2174/1568026611212230007 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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