Abstract
Peroxisomal proliferator activated receptor γ(PPARγ) belongs to the family of nuclear hormone receptors (NHRs), which directly regulate transcription of target genes. The regulatory role of this receptor on lipid metabolism and insulin sensitization is well established. Recently, the overexpression of this receptor in many human cancers has been identified and understanding its biological significance forms the current theme. PPARγ activation by specific agonists leads to growth inhibition, apoptosis and differentiation of tumor cells. PPARγ possess evident tumor promoting properties but the receptor independent effects of its ligands compound the understanding of its biology in cancers. This review highlights the multifaceted role of PPARγ in cancer progression with specific reference to colon, breast, gastric, lung and urological cancers. Molecular events as well as the mediators involved are analyzed in detail along with PPARγ independent effects of ligands under each cancer type. The crucial cross talk that exists between Wnt and PPARγ signaling is also summarized. An attempt has been made to identify the existing lacunae in understanding the biology of PPARγ in cancers along with suggestions for possible rectification.
Keywords: PPAR, receptor, Wnt, breast cancer, colon cancer, gastric cancer, lung cancer, urological cancer
Current Molecular Medicine
Title: Biology of PPARγ in Cancer: A Critical Review on Existing Lacunae
Volume: 7 Issue: 6
Author(s): Anand Krishnan, S. Asha Nair and M. Radhakrishna Pillai
Affiliation:
Keywords: PPAR, receptor, Wnt, breast cancer, colon cancer, gastric cancer, lung cancer, urological cancer
Abstract: Peroxisomal proliferator activated receptor γ(PPARγ) belongs to the family of nuclear hormone receptors (NHRs), which directly regulate transcription of target genes. The regulatory role of this receptor on lipid metabolism and insulin sensitization is well established. Recently, the overexpression of this receptor in many human cancers has been identified and understanding its biological significance forms the current theme. PPARγ activation by specific agonists leads to growth inhibition, apoptosis and differentiation of tumor cells. PPARγ possess evident tumor promoting properties but the receptor independent effects of its ligands compound the understanding of its biology in cancers. This review highlights the multifaceted role of PPARγ in cancer progression with specific reference to colon, breast, gastric, lung and urological cancers. Molecular events as well as the mediators involved are analyzed in detail along with PPARγ independent effects of ligands under each cancer type. The crucial cross talk that exists between Wnt and PPARγ signaling is also summarized. An attempt has been made to identify the existing lacunae in understanding the biology of PPARγ in cancers along with suggestions for possible rectification.
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Cite this article as:
Krishnan Anand, Nair Asha S. and Pillai Radhakrishna M., Biology of PPARγ in Cancer: A Critical Review on Existing Lacunae, Current Molecular Medicine 2007; 7 (6) . https://dx.doi.org/10.2174/156652407781695765
DOI https://dx.doi.org/10.2174/156652407781695765 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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