Bioactive Peptides from Marine Organisms: A Short Overview

Fernando      Lazcano-Perez; Sergio      A. Roman-Gonzalez; Nuria      Sanchez-Puig; Roberto      Arreguin- Espinosa

Abstract

Marine organisms are an immense source of new biologically active compounds. These compounds are unique because the aqueous environment requires a high demand of specific and potent bioactive molecules. Diverse peptides with a wide range of biological activities have been discovered, including antimicrobial, antitumoral, and antiviral activities and toxins amongst others. These proteins have been isolated from different phyla such as Porifera, Cnidaria, Nemertina, Crustacea, Mollusca, Echinodermata and Craniata. Purification techniques used to isolate these peptides include classical chromatographic methods such as gel filtration, ionic exchange and reverse-phase HPLC. Multiple in vivo and in vitro bioassays are coupled to the purification process to search for the biological activity of interest. The growing interest to study marine natural products results from the discovery of novel pharmacological tools including potent anticancer drugs now in clinical trials. This review presents examples of interesting peptides obtained from different marine organisms that have medical relevance. It also presents some of the common methods used to isolate and characterize them.

Keywords: Marine toxins, reverse-phase HPLC, peptides, chromatography, biologically active , gel filtration, pharmacological tools, anticancer drugs, Marine biodiversity, micro-organisms