Abstract
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive procedure whereby a pulsed magnetic field stimulates electrical activity in the brain. Parkinson's disease (PD) is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based treatments remain elusive. Consequently, more advanced non-invasive therapeutic methods are required. A possible method of rehabilitation that may be effective and potentially viable for use in clinical practice is rTMS. Here, we focus on the basic foundation of rTMS, the main findings of rTMS from animal models, the effects of rTMS on sensorimotor integration in patients with PD, and the experimental advances of rTMS that may become a viable clinical application to treat the disease.
Keywords: rTMS, Parkinsons disease, cellular and molecular mechanisms, Neurorehabilitation, Sensorimotor integration, Deep brain stimulation, HPLC, Prefrontal cortex, L-DOPA, iTBS
CNS & Neurological Disorders - Drug Targets
Title: Is rTMS an Effective Therapeutic Strategy that Can Be Used to Treat Parkinson's Disease?
Volume: 10 Issue: 6
Author(s): Oscar Arias-Carrion, Sergio Machado, Flavia Paes, Bruna Velasques, Silmar Teixeira, Lizbeth Cardenas-Morales, Roberto Piedade, Pedro Ribeiro and Antonio E. Nardi
Affiliation:
Keywords: rTMS, Parkinsons disease, cellular and molecular mechanisms, Neurorehabilitation, Sensorimotor integration, Deep brain stimulation, HPLC, Prefrontal cortex, L-DOPA, iTBS
Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive procedure whereby a pulsed magnetic field stimulates electrical activity in the brain. Parkinson's disease (PD) is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based treatments remain elusive. Consequently, more advanced non-invasive therapeutic methods are required. A possible method of rehabilitation that may be effective and potentially viable for use in clinical practice is rTMS. Here, we focus on the basic foundation of rTMS, the main findings of rTMS from animal models, the effects of rTMS on sensorimotor integration in patients with PD, and the experimental advances of rTMS that may become a viable clinical application to treat the disease.
Export Options
About this article
Cite this article as:
Arias-Carrion Oscar, Machado Sergio, Paes Flavia, Velasques Bruna, Teixeira Silmar, Cardenas-Morales Lizbeth, Piedade Roberto, Ribeiro Pedro and E. Nardi Antonio, Is rTMS an Effective Therapeutic Strategy that Can Be Used to Treat Parkinson's Disease?, CNS & Neurological Disorders - Drug Targets 2011; 10 (6) . https://dx.doi.org/10.2174/187152711797247821
DOI https://dx.doi.org/10.2174/187152711797247821 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Insights in Specific Cerebellar and Cerebral Activations in Blind Subjects
Current Medical Imaging Preterm Labour: An Overview of Current and Emerging Therapeutics
Current Medicinal Chemistry Microemulsions Based Transdermal Drug Delivery Systems
Current Drug Discovery Technologies Sphingosine-1-Phosphate Receptors in the Central Nervous and Immune Systems
Current Drug Targets Key Role of Mitochondria in Alzheimer’s Disease Synaptic Dysfunction
Current Pharmaceutical Design Clinical Phenotype and Mutation Spectrum of Alzheimer’s Disease with Causative Genetic Mutation in a Chinese Cohort
Current Alzheimer Research A Brief History of ‘Lone’ Atrial Fibrillation: From ‘A Peculiar Pulse Irregularity’ to a Modern Public Health Concern
Current Pharmaceutical Design α7 Nicotinic Acetylcholine Receptor Mediated Neuroprotection in Parkinson’s Disease
Current Drug Targets Investigation on Risk Factor of Vascular Thrombotic Diseases in Patients with Obstructive Sleep Apnea Hypopnea Syndrome
Vascular Disease Prevention (Discontinued) Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue
Current Drug Targets Neurotuberculosis: An Overview
Central Nervous System Agents in Medicinal Chemistry Difficulty with Uncertainty: How It Presents in Eating Disorders and What We Can Do About it
Adolescent Psychiatry Safety and Complications Reporting Update on the Re-Implantation of Culture-Expanded Mesenchymal Stem Cells Using Autologous Platelet Lysate Technique
Current Stem Cell Research & Therapy Quantitative Analysis of Microbial Metabolism in the Human Large Intestine
Current Nutrition & Food Science Promiscuous Seven Transmembrane Receptors Sensing L-α-amino Acids
Current Pharmaceutical Design Towards Retinoid Therapy for Alzheimers Disease
Current Alzheimer Research 123I-Ioflupane SPECT and 18F-FDG PET Combined Use in the Characterization of Movement and Cognitive Associated Disorders in Neurodegenerative Diseases
Current Alzheimer Research Rac-1 as a New Therapeutic Target in Cerebro- and Cardio-Vascular Diseases
Current Drug Targets Advances in Stem Cells Transplantation for the Therapy of Parkinson’s Disease
Current Stem Cell Research & Therapy Nanotherapeutics in Neuropathologies: Obstacles, Challenges and Recent Advancements in CNS Targeted Drug Delivery Systems
Current Neuropharmacology