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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Inflammatory Caspases: Targets for Novel Therapies

Author(s): Sigrid Cornelis, Kristof Kersse, Nele Festjens, Mohamed Lamkanfi and Peter Vandenabeele

Volume 13 , Issue 4 , 2007

Page: [367 - 385] Pages: 19

DOI: 10.2174/138161207780163006

Price: $65

Abstract

This review provides an overview of the biochemistry and activation of inflammatory caspases, and focuses on their therapeutic potential as disease targets in pathologies such as sepsis, Crohns disease, rheumatoid arthritis, traumatic brain injury and amyotrophic lateral sclerosis (ALS). We summarize the proof-of-principal evidence obtained by studies in several corresponding experimental disease models confirming the validity of strategies targeting inflammatory caspases. We discuss the use of inflammatory caspase inhibitors, such as VX-740 (Pralnacasan) and VX-765, in clinical studies for rheumatoid arthritis and osteoarthritis. Finally, we point out recent approaches identifying novel peptidomimetic or non-peptide caspase inhibitors with suitable clinical profiles.

Keywords: Peptide inhibitor, caspases, apoptosis, neurodegeneration, inflammation, inflammasome, utoimmune disease, pralnacasan, animal model


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