Abstract
The activity of caspase-2 was examined under varying biochemical conditions with the synthetic and protein substrates, Bid and procaspase-7. The results indicate that it was largely influenced by pH which might be one reason behind the inconsistency for the cleavage of its established substrates during caspase-2-induced apoptosis.
Protein & Peptide Letters
Title: Efficient Cleavage of Bid and Procaspase-7 by Caspase-2 at Lower pH
Volume: 15 Issue: 10
Author(s): Pratap Karki, Giri Raj Dahal, Song Yub Shin, Jung Sup Lee, Byungyun Cho and Il-Seon Park
Affiliation:
Keywords: Caspase-2, caspase-8, pH, salt, Bid, procaspase-7
Abstract: The activity of caspase-2 was examined under varying biochemical conditions with the synthetic and protein substrates, Bid and procaspase-7. The results indicate that it was largely influenced by pH which might be one reason behind the inconsistency for the cleavage of its established substrates during caspase-2-induced apoptosis.
Export Options
About this article
Cite this article as:
Karki Pratap, Dahal Raj Giri, Shin Yub Song, Lee Sup Jung, Cho Byungyun and Park Il-Seon, Efficient Cleavage of Bid and Procaspase-7 by Caspase-2 at Lower pH, Protein & Peptide Letters 2008; 15 (10) . https://dx.doi.org/10.2174/092986608786071193
DOI https://dx.doi.org/10.2174/092986608786071193 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Activation of Brain Endothelium by Soluble Aggregates of the Amyloid-β Protein Involves Nuclear Factor-κB
Current Alzheimer Research Regulation of Insulin Release at Pre-exocytotic Stages of the Secretory Process
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Targeted Radionuclide Therapy - An Overview
Current Radiopharmaceuticals Harnessing the Natural Pool of Polyketide and Non-ribosomal Peptide Family: A Route Map towards Novel Drug Development
Current Molecular Pharmacology Role of the Renin-Angiotensin-Aldosterone System in the Pathogenesis of Atherosclerosis
Current Pharmaceutical Design Anticancer Drug Design Using Scaffolds of β-Lactams, Sulfonamides, Quinoline, Quinoxaline and Natural Products. Drugs Advances in Clinical Trials
Current Medicinal Chemistry Defining the Mechanism of Action of 4-Phenylbutyrate to Develop a Small-Molecule-Based Therapy for Alzheimers Disease
Current Medicinal Chemistry Molecular Imaging of Breast Cancer: Role of RGD Peptides
Mini-Reviews in Medicinal Chemistry Acetylcholine Receptors and Tau Phosphorylation
Current Molecular Medicine Plant and Animal Steroids a New Hope to Search for Antiviral Agents
Current Medicinal Chemistry Emerging Role of Wnt/Beta-Catenin Signalling Pathways in Cancer Progression and Role of Small Molecule Tankyrase Inhibitors in Combating Multistage Cancers
Current Cancer Therapy Reviews Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease
CNS & Neurological Disorders - Drug Targets P2X Receptors and Inflammation
Current Medicinal Chemistry The Emerging Role of NRAS Mutations in Colorectal Cancer Patients Selected for Anti-EGFR Therapies
Reviews on Recent Clinical Trials Membrane Rafts in the Respiratory System
Current Respiratory Medicine Reviews Antiproliferative Activity of microRNA-125a and its Molecular Targets
MicroRNA Roles of p75NTR in Maintaining Brain Hemostasis and the Implications for p75NTR-targeted Therapies
Current Alzheimer Research Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease
Current Topics in Medicinal Chemistry Current Prodrug Design for Drug Discovery
Current Pharmaceutical Design Decision Support System for Lymphoma Classification
Current Medical Imaging