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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Using Feature Selection Technique for Drug-Target Interaction Networks Prediction

Author(s): W. Yu, Z. Jiang, J. Wang and R. Tao

Volume 18 , Issue 36 , 2011

Page: [5687 - 5693] Pages: 7

DOI: 10.2174/092986711798347270

Price: $65


Elucidating the interaction relationship between target proteins and all drugs is critical for the discovery of new drug targets. However, it is a big challenge to integrate and optimize different feature information into one single “knowledge view” for drug-target interaction prediction. In this article, a feature selection method was proposed to rank the original feature sets. Then, an improved bipartite learning graph method was used to predict four types of drug-target datasets based on the optimized feature subsets. The crossvalidation results demonstrate that the proposed method can provide superior performance than previous method on four classes of drug target families.

Keywords: Drug-target interaction, feature selection method, improved bipartite learning graph method, Elucidating, target proteins, drug target families, biological macromolecules, pathological states, drug targets undetectably, algorithm

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