Abstract
Gene therapy is an important tool in the treatment of many diseases involving malfunctioning of deoxyribo nucleic acid (DNA). Development of various techniques for efficiently transferring and expression of recombinant DNA or ribonucleic acid (RNA) at target site is a significant challenge. Viral vectors which have been used classically have a number of restrictions due to their induced toxicity and immunogenicity, the limited size of DNA that can be carried, the lack of specificity and the high cost of production. To overcome these problems nonviral vectors like nanoparticles, dendrimers, molecular conjugates, liposomes, microbubbles etc. are being explored. This review encompasses the details of these nonviral vectors.
Keywords: Efficiency, gene delivery, nonviral, transfection, vector, viral, Nanoparticles, Dendriplexes, Molecular Conjugates, Microbubbles
Current Drug Therapy
Title: Advanced Vectors for Gene Delivery
Volume: 6 Issue: 4
Author(s): Rajashree Hirlekar, Pramod Jagtap and Vilasrao Kadam
Affiliation:
Keywords: Efficiency, gene delivery, nonviral, transfection, vector, viral, Nanoparticles, Dendriplexes, Molecular Conjugates, Microbubbles
Abstract: Gene therapy is an important tool in the treatment of many diseases involving malfunctioning of deoxyribo nucleic acid (DNA). Development of various techniques for efficiently transferring and expression of recombinant DNA or ribonucleic acid (RNA) at target site is a significant challenge. Viral vectors which have been used classically have a number of restrictions due to their induced toxicity and immunogenicity, the limited size of DNA that can be carried, the lack of specificity and the high cost of production. To overcome these problems nonviral vectors like nanoparticles, dendrimers, molecular conjugates, liposomes, microbubbles etc. are being explored. This review encompasses the details of these nonviral vectors.
Export Options
About this article
Cite this article as:
Hirlekar Rajashree, Jagtap Pramod and Kadam Vilasrao, Advanced Vectors for Gene Delivery, Current Drug Therapy 2011; 6 (4) . https://dx.doi.org/10.2174/157488511798109600
DOI https://dx.doi.org/10.2174/157488511798109600 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
B7-H3-targeted Radioimmunotherapy of Human Cancer
Current Medicinal Chemistry Solvent-Free Synthesis of New 3’H-spiro[indole-3,2’-[1,3]]benzothiazole- 2(1H)-one Derivatives Using Michael Reaction
Letters in Organic Chemistry The Adenine Nucleotide Translocator: A New Potential Chemotherapeutic Target
Current Drug Targets Non-Surgical Treatment Options for Symptomatic Uterine Leiomyomas
Current Women`s Health Reviews The Role of NF-κB Inhibitors in Cell Response to Radiation
Current Medicinal Chemistry Polyphenols Counteract Tumor Cell Chemoresistance Conferred by Multidrug Resistance Proteins
Anti-Cancer Agents in Medicinal Chemistry Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier
Current Pharmaceutical Design The Functions of Heparanase in Human Diseases
Mini-Reviews in Medicinal Chemistry Syntheses and Preliminary Evaluation of Dual Target PET Probe [<sup>18</sup>F]-NOTA-Gly3- E (2PEG4-RGD-WH701) for PET Imaging of Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry Stable Gastric Pentadecapeptide BPC 157-NO-system Relation
Current Pharmaceutical Design The Effects of Colchicum baytopiorum on Regulatory Genes of Apoptotic and Autophagic Cell Death in HeLa Cells
Current Pharmaceutical Biotechnology Autism Spectrum Disorder Detection with Machine Learning Methods
Current Psychiatry Research and Reviews Cytotoxic Constituents of the Vietnamese Sea Snail Monodonta labio (Linnaeus, 1758)
Letters in Organic Chemistry The Potential Role of Pharmacogenomic and Genomic in the Adjuvant Treatment of Early Stage Non Small Cell Lung Cancer
Current Genomics Doxorubicin Sensitizes the Non-Small Cell Lung Cancer Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated (TRAIL) Apoptosis In Vitro but not In Vivo
Letters in Drug Design & Discovery A Functional Scaffold in Marine Alkaloid: An Anticancer Moiety for Human
Current Medicinal Chemistry Targeted Angiogenesis Therapy in Head and Neck Squamous Cell Carcinomas
Current Angiogenesis (Discontinued) Development of Human Papillomavirus (HPV) Vaccines: A Review of Literature and Clinical Update
Reviews on Recent Clinical Trials Prophylactic Vaccine Approach for Colon and Pancreatic Cancers: Present and Future
Current Medicinal Chemistry Application of Recombinant and Non-Recombinant Peptides in the Determination of Tumor Response to Cancer Therapy
Current Pharmaceutical Biotechnology