Abstract
Sulfated oligosaccharides display an important role in biological processes. They bind proteins through interactions mediated by highly specific sequences (heparin – antithrombin, heparan sulfate – growth factors / herpes simplex virus) or by electrostatic interaction between sulfate groups and cationic sites of proteins. Sulfated oligosaccharides are involved in biological events as protein localisation at cell surfaces, the control of proteolysis, the modulation of the angiogenesis and metastasis of tumours, the oligomerisation of cell growth factors. Sulfated residues have been recently found in glycoproteins, as GlcNAc or Mannose in N-glycosidic chains of different sources: gp120 of HIV, the envelope glycoprotein of influenza virus, the cysteine protease of Trypanosoma cruzi. This paper reviews recent findings concerning the implication of sulfated sugars in carbohydrate – protein interactions, from glycosaminoglycans to glycosidic chains in proteins, and their potential application as new targets for drugs/vaccines/diagnosis developments will be discussed. New approaches for their detection and analysis (ESI-MS, MALDI, Molecular Imprinting) are presented.
Current Medicinal Chemistry
Title: Sulfated Oligosaccharides: New Targets for Drug Development?
Volume: 16 Issue: 18
Author(s): Jose Kovensky
Affiliation:
Abstract: Sulfated oligosaccharides display an important role in biological processes. They bind proteins through interactions mediated by highly specific sequences (heparin – antithrombin, heparan sulfate – growth factors / herpes simplex virus) or by electrostatic interaction between sulfate groups and cationic sites of proteins. Sulfated oligosaccharides are involved in biological events as protein localisation at cell surfaces, the control of proteolysis, the modulation of the angiogenesis and metastasis of tumours, the oligomerisation of cell growth factors. Sulfated residues have been recently found in glycoproteins, as GlcNAc or Mannose in N-glycosidic chains of different sources: gp120 of HIV, the envelope glycoprotein of influenza virus, the cysteine protease of Trypanosoma cruzi. This paper reviews recent findings concerning the implication of sulfated sugars in carbohydrate – protein interactions, from glycosaminoglycans to glycosidic chains in proteins, and their potential application as new targets for drugs/vaccines/diagnosis developments will be discussed. New approaches for their detection and analysis (ESI-MS, MALDI, Molecular Imprinting) are presented.
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Cite this article as:
Kovensky Jose, Sulfated Oligosaccharides: New Targets for Drug Development?, Current Medicinal Chemistry 2009; 16 (18) . https://dx.doi.org/10.2174/092986709788453096
DOI https://dx.doi.org/10.2174/092986709788453096 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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