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Review Article

Evaluation of the Effect of Chelating Arms and Carrier Agents on t he Radiotoxicity of TAT Agents

Author(s): Soghra Farzipour, Zahra Shaghaghi, Marziyeh Raeispour, Maryam Alvandi*, Fatemeh Jalali and Amirhossein Yazdi

Volume 16, Issue 1, 2023

Published on: 03 October, 2022

Page: [2 - 22] Pages: 21

DOI: 10.2174/1874471015666220510161047

Price: $65

Abstract

Targeted Alpha Therapy (TAT) is considered an evolving therapeutic option for cancer cells, in which a carrier molecule labeling with an α-emitter radionuclide make the bond with a specific functional or molecular target. α-particles with high Linear Energy Transfer (LET) own an increased Relative Biological Effectiveness (RBE) over common β-emitting radionuclides. Normal tissue toxicity due to non-specific uptake of mother and daughter α-emitter radionuclides seems to be the main conflict in clinical applications. The present survey reviews the available preclinical and clinical studies investigating healthy tissue toxicity of the applicable α -emitters and particular strategies proposed for optimizing targeted alpha therapy success in cancer patients.

Keywords: Targeted alpha therapy, radiotoxicity, radiobiology, dosimetry, chelator, carrier.

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Graphical Abstract

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