摘要
背景:传统药物和中药配方作为活性新药的主要来源和中心,初步研究集中在提取和分离生物活性铅化合物(s),以治疗几种主要的癌症疾病。植物衍生的天然产物及其类似物揭示了几种临床有用的抗癌药物的重要来源。几十年来,草药和草药衍生的活性化合物在治疗、药物发现和传递中发挥着不可避免的作用,许多现有的标记药物和临床开发中的各种癌症相关分子靶点证明了这一点。 目的:通过适当的分子修饰,可以克服药物的溶解性、耐药性和代谢局限性。由于肿瘤靶向技术的增强,一些在早期临床研究中失败的药物也激发了新的兴趣。在这方面,体外-体内相关性(IVIVC)在制药技术领域剂型的发展中起着重要作用。 结论:IVIVC工具快速、提高药物开发过程和产品质量,用于内部控制,改进配方和替代生产过程。最重要的是,这个IVIVC工具减少了新药开发过程中人类研究的数量。在这篇综述中,我们想让读者注意IVIVC对抗癌药物天然产物的重要性和意义,如多西他赛、磷酸异扑苷、6-姜醇、辣椒素等。
关键词: 癌症,化疗,体外-体内相关性(IVIVC),草药,抗癌药物,治疗。
Current Drug Targets
Title:Potential Role of In Vitro-In Vivo Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs
Volume: 22 Issue: 12
关键词: 癌症,化疗,体外-体内相关性(IVIVC),草药,抗癌药物,治疗。
摘要:
Background: Conventional medicines, along with herbal formulations of Chinese, serve as the primary source and hub of active new drugs where the initial research concentrates on the extraction and isolation of bioactive lead compound(s) to treat several diseases largely for cancer. Plant-derived natural products and their analogs reveal a significant source of several clinically useful anticancer agents. Herbs and herbal derived active compounds play an unavoidable role in the treatment, drug discovery and delivery for decades, as evidenced by numerous existing marked drugs and various cancer-related molecular targets in clinical development.
Objective: Solubility, resistance and metabolic limitations of the drug can be overcome by suitable molecular modifications. Due to enhancements in tumor targeting technology, some agents who failed in earlier clinical studies are also stimulating renewed interest. In this connection, In Vitro-In Vivo Correlation (IVIVC) plays an important role in the development of dosage forms in the field of pharmaceutical technology.
Conclusion: IVIVC tool fastens and improves the drug development process and product quality, which is also utilized in internal control for scale-up to improve formulations and alternative production processes. Most importantly, this IVIVC tool lessens the number of human studies during new pharmaceuticals developments. In this review, we would like to grab the attention of readers to the importance and significance of IVIVC for natural products of anticancer drugs examples such as Docetaxel, Etoposide phosphate, 6-Gingerol, Capsaicin, etc.
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Cite this article as:
Potential Role of In Vitro-In Vivo Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs, Current Drug Targets 2021; 22 (12) . https://dx.doi.org/10.2174/1389450121999201113110433
DOI https://dx.doi.org/10.2174/1389450121999201113110433 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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