摘要
背景:糖尿病(DM)是一种严重的内分泌代谢性疾病,并伴有各种长期并发症。然而,已经确定了过多的目标,但可能会有不利的影响。因此,研究人员一直在寻找安全和更有效的治疗方法。天然产物,特别是来自植物,已被证明通过多种机制发挥抗糖尿病作用。 方法:综述糖尿病发病机制及其微血管并发症。提供了草药治疗糖尿病管理的可能潜在机制,突出了一些关键的治疗靶点。该综述还评价了草药产品通过调节炎症和肠道微生物群治疗糖尿病的最新进展。最后,我们讨论了目前可用的药物治疗方法。 结果:结果表明,许多植物已被证明是胰岛素分泌剂、α-葡萄糖苷酶和α-淀粉酶抑制剂的良好来源。在非常规靶点中,抑制脂肪酶、胆碱酯酶和血管紧张素转换酶等关键酶已直接和/或间接地与糖尿病和糖尿病并发症有关。例如,从穿孔金丝桃中分离的金丝霉素、假金丝霉素和I3、ii8-双芹菜素,以及从金金丝桃中分离的棕榈和钴胺。W.T.Wang&P.K分别被发现是强大的脂肪酶和胆碱酯酶抑制剂。此外,据报道,许多植物衍生化合物如玉米麸、黄芩素和小檗碱的铁酰化低聚糖通过调节肠道微生物群介导抗糖尿病特性。 结论:本综述中积累的信息有望为支持天然抗糖尿病药物开发的先进研究提供有用的科学基线信息。
关键词: 糖尿病,微生物组,脂肪酶,胆碱酯酶,血管紧张素转换酶,药物。
Current Medicinal Chemistry
Title:Conventional and Non-Conventional Targets of Natural Products in the Management of Diabetes Mellitus and Associated Complications
Volume: 28 Issue: 23
关键词: 糖尿病,微生物组,脂肪酶,胆碱酯酶,血管紧张素转换酶,药物。
摘要:
Background: Diabetes Mellitus (DM) is a severe endocrine metabolic disease coupled with various long-term complications. A plethora of targets have been identified, however, with possible adverse effects. Therefore, researchers are in the perpetual quest for safe and more effective therapeutics. Natural products, particularly derived from plants, have proven to exert anti-diabetic effects via diverse mechanisms.
Methods: An overview of DM pathogenesis and its associated micro- and macro-vascular complications is presented. Possible underlying mechanisms of herbal remedies in DM management are provided, highlighting some key therapeutic targets. The review also appraises the recent progress of herbal products in treating DM through regulating inflammation and gut microbiota. Finally, currently available pharmacological treatments are discussed.
Results: The results show that numerous plants have proven to be promising sources of insulin secreting agents, α-glucosidase and α-amylase inhibitors. Among the non- conventional targets, inhibition of key enzymes such as lipase, cholinesterases and angiotensin converting enzyme has been directly and/or indirectly linked to DM and DM complications. For instance, hypericin, pseudohypericin and I3,II8-biapigenin isolated from Hypericum perforatum L., and palmatine and columbamine isolated from Dichocarpum auriculatum (Franch.) W. T. Wang & P. K have been found to be powerful lipase and cholinesterase inhibitors, respectively. Moreover, a number of plant-derived compounds such as feruloylated oligosaccharides from maize bran, baicalein and berberine are reported to mediate anti-diabetic property via modulation of gut microbiota.
Conclusion: The information amassed in this review is anticipated to provide useful scientific baseline information to support advanced research in natural antidiabetic drug development.
Export Options
About this article
Cite this article as:
Conventional and Non-Conventional Targets of Natural Products in the Management of Diabetes Mellitus and Associated Complications, Current Medicinal Chemistry 2021; 28 (23) . https://dx.doi.org/10.2174/0929867327666201102120120
DOI https://dx.doi.org/10.2174/0929867327666201102120120 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cardiac Side Effects of Chemotherapy: State of Art and Strategies for a Correct Management
Current Vascular Pharmacology The C242T CYBA Polymorphism as a Major Determinant of NADPH Oxidase Activity in Patients with Cardiovascular Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry The Fibroblast Growth Factor 23: A New Player in the Field of Cardiovascular, Bone and Renal Disease
Current Vascular Pharmacology Restoring the Dysfunctional Endothelium
Current Pharmaceutical Design Pharmacological Treatments for Obesity-Related Hypertension
Current Hypertension Reviews Revascularization vs. Optimal Medical Therapy in Women with NSTE-ACS
Current Pharmaceutical Design Repetitive Transcranial Magnetic Stimulation to Treat Substance Use Disorders and Compulsive Behavior
CNS & Neurological Disorders - Drug Targets Role of miRNAs in Muscle Stem Cell Biology: Proliferation, Differentiation and Death
Current Pharmaceutical Design MicroRNAs in Breast Cancer: One More Turn in Regulation
Current Drug Targets Susceptibility of Helicobacter pylori to Natural Products: Can Past Research Direct Future Drug Development?
Current Bioactive Compounds Obesity and Pregnancy
Current Women`s Health Reviews Novel Anti-arrhythmic Medications in the Treatment of Atrial Fibrillation
Current Cardiology Reviews Prognosis and Treatment of Ventricular Arrhythmias Following Myocardial Infarction
Current Cardiology Reviews Beneficial Effects of Statins on Endothelial Dysfunction and Vascular Stiffness
Current Vascular Pharmacology Pulmonary Valve Endocarditis: A Case Report
Infectious Disorders - Drug Targets Pregnancy-Associated Plasma Protein-A and its Role in Cardiovascular Disease. Biology, Experimental/Clinical Evidences and Potential Therapeutic Approaches
Current Vascular Pharmacology Epigenetic Regulation of Osteogenic Differentiation of Mesenchymal Stem Cells
Current Stem Cell Research & Therapy State-of-the-Art Review of Current Therapies for HFpEF: An Overview of Interatrial Septal Device Therapy in Heart Failure
Current Cardiology Reviews Inotropic Therapies in Asphyxiated Neonates: The Clinical and Laboratory Facts
Current Pediatric Reviews C-reactive Protein, Infection, and Outcome After Acute Ischemic Stroke: A Registry and Systematic Review
Current Neurovascular Research